新生儿出生体质量与成年后尿微量蛋白及尿肌酐相关性的临床研究

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【中图分类号】R692；R814.42【文献标志码】A【收稿日期】2024-12-19

Correlation of neonatal birth weight with urinary microproteins andcreatinine inadulthood

Ding Zijun，Wang Xiaolin （Department of Pediatrics，Shanxi Medical University）

【AbstractObjective：Toinvestigate thecorelationandcausalelationshipbetweenneonatalbirthweightandurinarymicoproteins andcreatinineinadulthod.Methods：Geome-wideasociationstudieswereconductedtoextract geneticlociwithsigificantinfluencefromdatasetasistrumentalvariables，ndtheywereanalyzedbyinversevariance weighted（IVW），weightedmedian，Ege， andMR-PRESSOmethods toinvestigatethecausalrelationshipbetweenneonatalbirthweightandurinarymicroproteinsandeatinineinadulthood.Aretrospectiveanalysisaspeformedfor113neonateshowereadmitedtoDepartmentofNeonatologyhani Children’sHspital，fromJauaryotoJanuaryOO，andrelateddatawerecolectedduringtheneonatalanddultstagesAPear soncorelationanalysisasusedtodeterminethecorelationbetweenneonatalbirthweightandurinarymicroproteinsandceatiine inadulthoodResults：TeMR-VWtestshowedtatneonatalbirtheigthadastatisticallsigniicantcorrelationithunaryicr proteins（ P=0 . 0 3 7 ）and urinary creatinine（ P=0 . 0 1 5 ） in adulthood. The retrospective study showed that there were no significant differencesbetween the two groups in all variables except body weight （ P>0 . 0 5 ）.Inaddition，the Pearson correlation analysis showed that neonatal birthweightwasnegativelycorrelated with urinarymicroproteins（ r = -0.78， P =0.015）and waspositively correlatedwith urinary creatinine（ r=0 . 7 8 ， P =0.018）.Conclusion：Neonatal birth weight is negatively correlated with urinary microproteins and is positivelycorrelatedwithurinarycreatinineinadulthood.

【Keywords】neonatal birth weight;urinary creatinine;urinary microproteins;Mendelianrandomization;Pearsoncorrelationanalysis

WHO将低出生体质量儿（lowbirthweitht，LBW）定义为出生体质量在 2 5 0 0 g 以下的新生儿。（剩余11460字）