肥胖2型糖尿病患者血清铁蛋白同型半胱氨酸水平变化 及其影响因素分析

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Analysis of the changes of serum ferritin and homocysteine levels and their influencing factors in obese patientswithtype2diabetes

ChenJiahui，LiZhanping，LiangYongli DepartmentofLaboratory，XinzhengHuaxinPeople'sHospital，Zhengzhou 4511Oo，China

【Abstract】ObjectiveTo investigate the changes of serum feritin （SF） and homocysteine （Hcy）levels and their influencing factors in obese type 2 diabetes melitus（T2DM） patients.MethodsThe study group consisted of 14O obese T2DM inpatientsadmited to Xinzheng Huaxin People's Livelihood Hospital from May 2022 to May 2024，and the control group consisted of140 non-obese/overweight T2DM patients matched by age and sex during the same period.t test was used to compare serum SF，Hcy，FFA，TG，TC and insulin resistance index （HOMA-IR）levels of patients withdifferent types of obesity in the two groups.Thecorrelationof serum SF， Hcy，TG，TCand HOMA-IR levelswasanalyzed byPearson method.Multivariate Logisticregresionanalysis of independent risk factors afecting serum SFand Hcylevels inobese T2DM patients.ResultsThe Hcy level in the study group was higher than that in the control group [（13.4±1.8） μmol/L vs. （9.8±1.3） μmol/L， P<0.05 ].The serum SF level of the study group was higher than that of the control group [（286±35）ng/ml vs. （237±32）ng/ml， P< 0.05].HcyandHOMA-IR （r=0.202，P=0.001），BMI （r=0.155，P=.011），FPG （r=0.256，P<0.001），TG（r=0.171， P=

0.007），TC （r=0.151，P=0.013），FINS（r=O.246，P<0.001） were positively correlated;SFand SBP（ =0.225，P< 0.001），TG（r=.169，P=0005），Hcy（r=0.175，P=0.004），FFA（r=0228，P<0.001），BMI （r=0.233，<0.00）， （r=0.154， P =0.012） and HOMA-IR （r=0.168， P =0.008） were positively correlated.Multivariate Logistic analysis showed thatSFwas correlated with BMI [OR（95%CI）=1.324（1.194，1.469），P<0.001]andFFA [OR（95%CI）=1.429 （1.231，1.659），P<0.001]. ConclusionSerum SF，Hcy，FFA，TG， HOMA-IRand blood pressure in obese T2DM patients are higher than those in simple T2DM patients，and high levels of BMI and FFA can affect SF level.

【Key words】 Diabetes mellitus，Type 2；Ferritins;Homocysteine; Insulin resistanceDOI：10.19522/j.cnki.1671-5098.2025.02.015

2型糖尿病（T2DM）的典型症状为多饮、多尿、多食和体质量下降，被称为“三多一少”，肥胖为早期肥胖T2DM的重要临床体征[1]。（剩余5515字）