血清同型半胱氨酸尿酸脑钠肽前体及尿微量白蛋白联合检验在慢性肾小球肾炎辅助诊断中的应用观察

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【Abstract】ObjectiveTo explore the value serum homocysteine (HCY),uric acid (UA),N-terminal pro-brain natriuretic peptide(NT-proBNP)and urinary microalbumin (U-mALB)in the auxiliary diagnosis chronic glomerulonephritis (CGN).MethodsSixty CGN patientsand sixty healthy physical examination patients admitted toour hospital from January 2O2Oto January 2O23 were selectedas the observation groupand the control group.Allblood samples were collected forHCY,UA,andNT-proBNP levels,andurine collection forU-mALB levels.Comparing HCY,UA,NT-proBNP and U-mALB levels between the two groups,and the diffrences CGN patients with different stages.ROC curve was used to analyze the clinical value each index to diagnose CGN. ResultsThe levels HCY,UA,NT-proBNP and U-mALB in the observation group [(19.0±1.5) μmol/L, (490 ± 43)μmol/L,(446±52)pg/ml,(32.6±3.5)mg/L],were higher than those in the control group[(9.2±1.2) μmol/L, (306±30) μmol/L, (201±20) pg/ml,(14.1±1.2) mg/L (P<0.05) ]; The levels HCY,UA,NT-proBNPand U-mALB instageIICGN patients [(25.7±2.3)μmolL,(543±50)μmol/L,(502±55) pg/ml, (40.52±4.19) mg/L] were higher than those in stage I and stage I CGN patients (P

【Key words】Glomerulonephritis;Homocysteine;Uric acid;Natriueretic peptide,brain;Urinary microalbumin;Diagnotis DOI:10.19522/j.cnki.1671-5098.2025.02.013

慢性肾小球肾炎(chronicglomerulonephritis,CGN)为常见肾脏病变,好发于中年男性群体,在肾小球损伤过程中,会影响肾脏的正常代谢,诱发血尿、蛋白尿、水肿等多种症状,一旦治疗不及时,肾损伤可持续进展,最终可导致尿毒症的发生,降低患者生存质量。(剩余6217字)

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