磁共振弹力值对非酒精性脂肪性肝病患者肝纤维化的定量评估及其与碱性磷酸酶天冬氨酸转氨酶的关系

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Quantitativeevaluationof liver fibrosis inpatientswith nonalcoholic fatty liver diseasebymagnetic resonance elastographyand its relationship with alkaline-phosphatase，aspartate-aminotransferase Lu Zhipeng

MedicalImagingDepartment，Zhengzhou People'sHospital，Zhengzhou45ooO3，China

【Abstract】ObjectiveTo analyze the quantitative evaluation of magnetic resonance elastography （MRE） values inassessing liver fibrosis in patients with non-alcoholic fatyliver disease（NAFLD）and to investigate its relationship with alkaline phosphatase （ALP）and aspartate aminotransferase （AST） levels.MethodsFifty patients with NAFLDadmitted toour hospital from January 2023 to December 2O23 were analyzed.Routine abdominal， magnetic resonance elastography （MRE），ALP and AST were detected before operation，and the clinical data of he patients were analyzed.ResultsTheresults showed that the degree of liver fibrosis was divided into 7cases of non-fibrotic stage（SO），12 cases of mildfibrotic stage （S1），12cases of significantfibrotic stage （S2），11casesof advanced fibrotic stage（S3）and8casesof cirrhosis stage（S4）.InNAFLDpatients，there were significant diferences in livermagneticresonance elasticityvalues inthediagnosis of mild liver fibrosis，significant liverfibrosis，advanced liver fibrosis and cirrhosis （all P<0.05 ）.The accuracy of MRI elasticity values in the diagnosis of mild liver fibrosis， significantliverfibrosis，advancedliverfibrosisandcirhosiswere0.90（95%CI0.81，0.96），0.91（95%CI0.83，0.98）， 0.93（95%CI 0.86，1.0）and 0.93（95%CI 0.84＼～），respectively1.00）.Among them，the sensitivityof livercirhosis was thehighest;forthediagnosisofmildliverfibrosis，thespecificitywasthe greatest.Pearsonlinearcorelationanalysis showed that in NAFLD patients，there was no significant correlation between liver magnetic resonance elasticity value and totalbilirubin，globulin，total proteinandalbumin（r=0.191，0.122，0.262，0.153，P>0.05），andthere wasa weak positive correlation with ALP（r=O.447，P

ConclusionMREcanbeusedasanefective evaluation tool for liver fibrosis inNAFLDpatients，and it is corelated with ALPand AST.Especially in the diagnosis of cirhosis，MREshows high sensitivityand is of great significance for earlydiagnosisand therapeutic intervention.

【Key words】Non-alcoholic fatty liver disease；Elasticity imaging techniques；Hepatic fibrosis；Alkaline phosphatase; Aspartate aminotransferases DOI：10.19522/j.cnki.1671-5098.2025.02.005

非酒精性脂肪性肝病（non-alcoholic fattyliver disease，NAFLD）是一种常见的代谢性疾病，其特征是肝脏内脂肪积累超过正常范围，没有其他显著的酒精消耗史或其他明显的肝病因素。（剩余6919字）