苍术-麻黄对血脂异常斑马鱼血脂水平及脂肪代谢的影响
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AbstractObjective：ToexplretheefectsofAtractylodes-Ephedraonlipidlevelsandfatmetabolisminzebrafishwithdyslipidemia. Methods：Thealbinozebrafishstrainwithmelaninalelemutationthatsem-transparentwasnaturallmatedinpairsforreproductionA totalof210fis3Ofisprgroup）wereselectdat7dayspostfertiatin7dpfforevaluatingelipid-oweinefectoftradioal Chinesemedicinedecoctions.Thealbinozebrafishstrainwithmelaninallemutationthatsemi-transparentwasnaturalymatedinpais forreprductioFivysorto5dpt），1iseeted3Ogop）fvaatitctofi medicinedecoctionsonadiposecatabolismResults：Comparedwiththemodelcontrolgroup，inthsimvastatingroupandthe5.50.， and 100.0μL/mL concentrationsof the Atractylodes-Ephedra formula groups，thesum of optical densitywerestatistically significantly different（ P<0.05 .Itwasdemonstratedthatat 40ng/mL simvastatinand25.0，50.0，and 100.0μL/mL ofAtractylodes-EphedraFormula hadlipid-loweringefectsonzebrafishwithdyslipidemiainducedbyeggyokpowder.Comparedwiththemodelcontrolgroupnthe simvastatin group and the 25.0，50.0，and 100.0μL/mL concentrations of the Atractylodes-Ephedra Formula，the TG levelsshowed statisticallysignificant differences ⌈P<0.05⌉ .Itwasdemonstrated thatatconcentrationsof 40ng/mL simvastatinand 25.0，50.0，and100.0 （204号 μL/μL f Atractylodes-EphedraFormula，theTGlevelsinzebrafishwithdysipidemiainducedbyeggyolk powderwerereduced. Comparedwiththemodelcontrolgroup，inthesimvastatingroupandthe12.5，25.0，50.0，and100.0 μL/mL concentrations of Atractylodes-Ephedra Formula group，theTC levelsshowedstatisticallysignificant differences（ P<0.05） .Itwas shown that at concentrations of simvastatin of 40ng/mL and of12.5，25.0，50.0，and 100.0 μL/mL ，theconcentrationof Atractylodes-Ephedra Formula couldreducetheTClevelofthezebrafishwithdysipidemiainducedbyeggyokpowderComparedwiththepositivecontrolgroupthere werestatisticalysifadifreesinteotaltaingintesityoftoksadadiposecatabolisiteesveratrogpdte 100.0μL/mL concentration group of the Atractylodes-Ephedra Formula（ （P<0.05） .ltwasshown thatataconcentrationof 14.4μ9/mL of resveratrol and 100.0μL/mL of Atractylodes-Ephedra Formula，there was a promoting efect on the adipose catabolism of zebrafish. Conclusion：Atractylodes-Ephedraherbshavetheefectofreducingtriglyceride（TG）andtotalcholesterolTC）levelsandpromoting adipose catabolism.
Keywordsdyslipidemia;Atractylodes;Ephedra; fat metabolism;zebrafish
血脂异常（dyslipidemia）通常指血清总胆固醇（totalcholesterol，TC）、三酰甘油（triglyceride，TG）、低密度脂蛋白胆固醇（low-densitylipoproteincholesterol，LDL-C）水平升高，高密度脂蛋白胆固醇（high-densitylipoproteincholesterol，HDL-C）水平降低[1]。（剩余5640字）
