基于《中国百年百名中医临床家丛书》探讨名家治疗不寐病的证型、证素与处方用药规律

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AbstractObjective：Toexploringthesyndromeelementsanddrugprescriptionpatesoffamousexpertsintreating insomniathrough dataminingMethods：emedicalcaseprescritinsfortreatinginsomniabyalltephysiciansiChineseHundredYearsandHundred TradionalCnedicininanserisereatisticalyaldndedroetyesdromeelementsdicatio paterswereanalyzedusingdataminingsoftware.Resuls：Atotalof114prescrptionsfortreatinginsomniaby32modefamous tradionalChinesemedicineexpertswereincluded，withatotalof197drugsandtotalfrequencyof1381times.Thity-fivesdroe types，eightsyndromeelementsofdiseaselocationand14syndromeelementsofdiseasenaturewereexracted.Atotalof 37high frequency drugs（frequency≥10） were used with 887 times，accounting for 64.23% ofalldrug frequencies.The high-frequency drugswere sorted，andthethreecommonlyuseddosagesandtheaplicationrangesofthedrugdosageswererespectivelycounted.Themost commonsyndrometypewasheartkidneydisharmonyheartwasthemaindiseaselocationandheatwasthemaindiseasetypeThe maincategoryofdrugsassedatives.hepropertiftemedcinewasmainlyneutralTemedicinaltasteasparicularlysweetAmong themeridians，teeartmeridianwastheghestone.Associationruleanalysisevealedthattherewere16combinations.Factoranalysis extracted14commonfactors.Systematicusteranalysisidentiedfivemajorcategories.Decisiontreeanalysisscreenedoutthreemain tradionalChinesemedicines，namelylicorice，thistleandstonecaia.Complexnetworkanalysisindicatedtatthecoredrugswere dragononeteubelieltaldout syndrometypessdrentsdpesiattsinreatfisiiefoctic

Keywordsinsomnia；ChineseHundredYearsandHundredTraditionalChineseMedicineClniciansSeries；syndrometypesand elements; prescription medication patterns; data mining

不寐病是以难以入睡、眠浅易醒，甚则整夜不能入睡为主要表现的临床常见病1，始载于《黄帝内经》，《黄帝内经》中称之为“目不瞑"“不得眠”“卧不安”[2]，相当于现代医学的睡眠障碍。（剩余6374字）