益气通络法干预ApoE-小鼠动脉粥样硬化模型有效性的系统评价

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AbstractObjective：ToevaluatethetherapeuticefectofthetraditionalChinesemedicinecompoundformulaofthetonifyingQiand unblockingmeridiansmethod in treating theatherosclerosismodel of ApoE-knockout（ApoE -1- ）mice.Methods：The databases of NationalKnowledgeInfrastructure（CKl），WanfangDataVIJoumalatabase，PubedandCochaneLibraryweresearchedfromte establishmentofthdatabasetoovember723.TheualtyoftheiteraturewasevauatedusingteRCLEtoolMetaanalysisas performedusingReview Manager.Results：Thecomparativestudyof traditionalChinesemedicinecompound prescriptionsandthe controlgroupinvolved12items.ThecomparativestudyoftraditionalChinesemedicinecompoundandstatingroupincluded10items.The comparisonofoutcomeindicatorsshowedthat thetradionalChinesemedicinecombinationcouldreducetheareaofatherosclerotic plaques in the mouse model（MD=-20.33， 95%C1 —27.18--13.47， P<0.00001 ），lower low-density lipoprotein cholesterol（LDL-C） 1 ND=-3.60 95%C1 —6.25--0.95， P=0.008 ），lowertotalcholesterol（TC） （M $n _ { Ḋ } = - 7 . 5 5 Ḍ$ 95%C1 —14.01-—1.10， P=0.02 ），increase high-density lipoprotein cholesterol（HDL-C） （ MD=0.82 95%C1 0.36-1.27， P=0.000 4 ），and lower triglycerides（TG） MD=-0.86 95%Cl —1.25--0.48， P<0.000 1].Thearea of atherosclerotic plaques between the positive control statin groupand the traditional Chinesemedicinecompoundgroupwerestilunstable.TereasnostatisicalysignificantdiferenceinLDL-C，TC，HD-CandG between the two groups P>0.05） .Conclusion：This study demonstrates that the traditional Chinese medicine compound of the tonifying Qiandunblockingmeridiansmethodcansignficantlymprovethelipidmetablismof theatherosclerosismodelinApoEmiceeduce theareaoftroleroticidiierapettoroseosiseompreditesio ofstatins，there isno statistically significant difference in improving lipid indicators.

Keywordsatherosclerosis;tonifying Qi and unblocking meridians; ApoE-knockout mice; Meta-analysis

动脉粥样硬化（atherosclerosis，AS）是导致心脑血管病的病理基础，具有重要的临床意义。（剩余8128字）