系统性红斑狼疮病人认知功能障碍非药物干预方案的构建及可行性研究
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Construction and feasibility study on non-pharmaceutical intervention program for cognitive dysfunction in patients with systemic lupus erythematosus
BIANWenjuan1²2，XU Renjul，ZHU Yuxuan1，ZHU Yantong1，ZHANG Yue'，ZHANG Qiong'，WEI Wei， LI Xianwen²，CHENYujie'
1.NanjingDrumTowerHospital，theAfiliatedHospitalofNanjing UniversityMedicalSchool，Jiangsu20008 China;2.School of Nursing，Nanjing Medical University
*Corresponding Author XU Renju，E-mail： 276506323@qq.com
AbstractObjective：Toconstructanon-pharmacologicalinterventionprogramforcognitiveimpaiment（CD）inpatients withsystemic lupuserythematosus（SLE）andtoevaluateitsfeasibilityMethods：Basedonacomplexinterventiondesignandevaluationframework，the non-pharmacological intervention program forcognitiveimpairment in patientswithsystemic lupuserythematosuswasconstructed throughevidence-basedresearchandstakeholderinterviews.Patientswithsystemiclupuserythematosuswhosoughtreatmentnthe rheumatologyandimmunologydepartmentofatertiaryhospitalinNanjingcityfromFebruarytoMarch2O25wererecruited.The constructedprogramwasusedtoimplementeinterventionforthepatientsandevaluateitsfeasibilityResults：Thenonphaacological interventionprogramfocognitiveimpaimentinpatientswithsystemiclupuseythematosusincluded5primaryindicatorsofogazatioal managementsstseltaidalatioad indicators.The on-site recruitment rate was 90.48% .The retention rate was 84.21% .The participation compliance rate was 84.21% .After 3monthsofinterentioxceptfortefactthattereasnoigificantdiereceinpainbetwnmonthand3mothsointeeti P>0.05） ，there werestatisticallysignificantdiferences infatigue，ainviaminDlevels，qualityoflife，ndcognitivefunctionatthree timepoints（ P<0.05 0.Conclusions：The non-pharmacological intervention program forcognitive dysfunction in patients with systemic lupusrythematosostrutedinisugodectieessndasibilitndouldprodefecefoiicalteif cognitive dysfunction in patients with systemic lupus erythematosus.
Keywordssystemiclupuseythematosus;cognitivedysfunction;nonpharmaceticalintervetion;schemeonstruction;feasblitystudy
系统性红斑狼疮（systemic lupuserythematosus，SLE）是好发于 15～40 岁育龄期女性的自身免疫性疾病，以累及多脏器、产生多种自身抗体和免疫复合物为特征[1]。（剩余14472字）