高原鼠不同地理种群MHC-DRB基因外显子2遗传多样性分析

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中图分类号：S812.6 文献标识码：A 文章编号：1007-0435（2026）03-0779-09

doi：10.11733/j.issn.1007-0435.2026.03.004

引用格式：，等.高原酚鼠不同地理种群MHC-DRB基因外显子2遗传多样性分析[J].草地学报， 2026，34（3）：779-787 GONGJun-qiang，HOUQi-qi，OU Ke-jie，et al. Analysis of Genetic DiversityofDiffrent Geographic Populations of Eospalax baileyi Based onMHC-DRB Exon 2 Gene[J]. Acta Agrestia Sinica，2O26，34（3）：779-787

Analysis of Genetic Diversity of Different Geographic Populations of Eospalax baileyi Based on MHC-DRB Exon 2 Gene

GONG Jun-qiang1.2，，HOU Qi-qi12，OU Ke-jie1²，HAO Biao-biao12，WANG Wen-bi12， SU Jun-hu1.2.3*

（1.SchoolofGrassand，GansuAgriculturalUniversitKeyLaboratoyofGrassandEcosystemMinistryofducationofauProvince/ GansuProvicialGrassandEngeringaboratorCenterfoustainableDevelopmentofGrassandAnialHusbandryofCinaandtUni States，LanzounsuProvince3Ohin；2.CenteforrasandiiversityResearchansuAgiculturalUniversityrc University，LaosuProviceOina；GuQashaGsandoteeationdeseachtatioWuwei Gansu Province 733200，China）

Abstract： To elucidate the genetic diversity and adaptive evolutionary mechanisms of different geographical populations of the plateau zokor（Eospalax baileyi），in this study PCR was conducted to amplify and clone the MHC-DRB gene exon 2 in 121 individuals from eight distinct geographical populations. The results showed that the MHC-DRB exon 2 of the plateau zokor exhibits high polymorphism，with significant genetic diferentiation among populations. Geographical isolation was identified as the primary factor driving population divergence. Codon usage bias was observed in nucleotide composition. Neutral tests indicated that the plateau zokor population had not undergone recent expansion，and the maintenance of genetic polymorphism was primarily driven by natural selection.The findings of this study willprovidea theoretical basis for further investigating the genetic adaptation of MHC genes in Eospalax baileyi and their effective population management.

Key words：Eospalax baileyi;MHC-DRB exon 2;Polymorphism;Genetic diversity;Selective effect

遗传多样性亦称基因多样性，是生物适应环境变化的基础[1]。（剩余13953字）