抗真菌药物的新型研发策略与前沿技术应用

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中图分类号：R978.5 文献标志码：A 文章编号：2097-7174（2026）03-0262-07

DOI：10.3969/j.issn.2097-7174. 2026.03.011

New research and development strategies and cutting-edge technology applications of antifungal drugs

HUANGBinbin，HE Xiyun，XUMingmin （School of Basic Medicine，Gannan Medical University，Ganzhou，Jiangxi 341000）

Abstract：Inthecontextoftheincreasingglobalburdenoffungalinfections，thedevelopmentofantifungal drugsfacs the dualchallnges of significant drug toxicityand escalating drug resistance.Thedevelopment of antifungal agents withlow toxicityandreducedresistance hasbecomeakeyresearch focus.Thisarticlesystematicallyreviews themechanismsand limitationsof currntantifungal drugs，witha particularemphasisonnovelresearch and development strategies basedon natural productdiscovery，structuraloptimization，drug repurposing，and nano-deliverysystems.Furthermore，it explores thecriticalrolesofcuting-edge technologies，suchasartificialintelligence，CRISPR-Cas9geneediting，high-throughput screening，andorganoid models innewdrugdesign，mechanismresearch，anddrugdevelopment evaluation.Byintegrating innovativeachievementsfrominterdisciplinaryfields，thisreviewaimstoprovideatheoretical foundationanddirectional guidance for the precisedesign，efficient screening，and clinical translation of antifungal drugs.

KeyWords：Antifungal drugs；Drug resistance；New research and development strategy；Thecutting-edge technology; Interdisciplinary

侵袭性真菌感染已成为全球公共卫生领域的重大威胁。（剩余17227字）