miR-92a在脑缺血再灌注损伤中的机制研究与治疗进展

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关键词：脑缺血再灌注损伤； miR-92a ；脑卒中

中图分类号：R743.31 文献标志码：A 文章编号：2097-7174（2026）03-0195-05

DOI：10.3969/j.issn. 2097-7174. 2026.03.001

The mechanism of miR-92a in cerebral ischemia-reperfusion injury and therapy progress

ZHONG Huimin 1# ，DING Jiamin1，TAO Yuanming1，HUANGKuang²，CHEN Li² （1.The First Clinical Medical School of Gannan Medical University；2. Department of Anesthesiology， TheFirst Afiliated Hospital College ofGannan Medical University，Ganzhou，Jiangxi 341000）

Abstract：Cerebral ischemia-reperfusion injury（CIRI） isacritical pathological processunderlying ischemic strokeand otheracute ischemic disorders.Itsmechanisms involve inflammation，blood-brain barier（BBB）disruption，oxidative stress，and neuronalapoptosis.Asakey memberof themiR-17-92cluster，miR-92a playsanimportant regulatoryrole in multiple celltypes of the neurovascular unit （NVU），including neurons，endothelial cells，pericytes，and astrocytes. Studies have shown that miR-92aaggravates inflammation，BBBdysfunction，oxidativestress，andneuronalapoptosis by inhibiting the expresion of KLF2/4，NRG1，and antioxidative moleculessuch as HO-1 and SIRT6，thereby exacerbating braininjury.Therefore，developing newtherapeuticstrategiestargetingthefunctionandregulatorymechanismsofmiR-92a has becomeanew focus inthefieldof CIRIresearch.This article reviews the multiple regulatory mechanisms of miR-92a in CIRI，aiming to provide new potential therapeutic targets and approaches for stroke.

Keywords：Cerebral ischemia-reperfusion injury；miR- .92a ;Stroke

脑卒中是全球成人致死致残的首要病因，其中缺血性脑卒中约占 87% ，治疗伴随的脑缺血再灌注损伤（Cerebral ischemia-reperfusion injury，CIRI）已成为心肺复苏、颅脑创伤等疾病的共同病理环节，涉及炎症、氧化应激、血脑屏障（Blood-brainbarrier，

BBB）破坏等复杂机制[1-3]。（剩余11048字）