高血压与焦虑抑郁共病机制的研究进展

中图分类号：R544.1；B842.6 文献标志码：A 文章编号：2097-7174（2026）03-0235-07

DOI：10.3969/j.issn.2097-7174.2026.03.007

Research progress on the comorbiditymechanismof hypertension andanxiety-depression

LIU Yunjiu’，LUO Xiaoting² （1.TheFirst Clinical Medical School ofGannan Medical University;2.Gannan Medical University， Ganzhou，Jiangxi341000）

Abstract：There isa large and growing population of people with hypertension in China，which brings a heavyhealth burdento society.Epidemiological investigations havefoundthat hypertensionandanxietyanddepresion oftencoexist and influenceeach other.Exploringthecomorbiditymechanismcanhelptreatboththebodyandmind，andreduce the complicationsand functionaldamageofhypertension.Intermsofpathophysiological mechansms，theposiblecomorbidity pathwaysbetweenthetwoincludetherenin-angiotensin-aldosteronesystem，thehypothalamic-pituitary-adrenalaxis，insulin resistance，and the locuscoeruleus-sympathetic-adrenal medullasystem.In traditional Chinesemedicinetheory，the comorbidityof hypertensionandanxietyanddepressionis essentiallyacomprehensive manifestationofthedysfunctionof internal organsand theimbalanceof qi，blood，yinand yang.The twoare closelyrelated through the imbalance of qi blood，yinandyangintheliver，kidney，spleen，heartandotherinternalorgans.Infutureresearch，bydeeplyexploring the comorbiditymechanismofthetwo，itisexpectedtoclarifytheir mutualrelationship，and intervening intheprocess canhelppreventand treat the disease.

Keywords：Hypertension；Anxiety；Depression；Comorbidity mechanism

高血压是遗传及环境因素共同作用的常见心血管疾病，以体循环动脉压升高为主要临床表现，是心脑血管疾病最重要的危险因素之一。（剩余13277字）