聚桂醇注射液致过敏性休克例

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【中图分类号】R593.1 【文献标识码】A

【Abstract】A 53-year-old male patient with hepatocellular carcinoma，liver cirrhosis， and peritoneal lymph node metastasis was admitted due to upper gastrointestinal bleeding. During gastrointestinal endoscopy， esophageal and gastric variceal bleeding was observed， and 2mL of lauromacrogol injection was injected. One minute after injection， the patient suddenly developed tachycardia （140 beats per minute）， hypotension （ 60/40mmHg ）， oxygen saturation of 80% ，and tachypnea， which were consistent with lauromacrogol-induced anaphylactic shock. The endoscopic procedure was immediately terminated， and anti-anaphylactic and anti-shock treatments were administered promptly， leading to rapid reversal of the shock symptoms.On the 3rd day of hospitalization，another endoscopy was performed without lauromacrogol injection，and no allergic reaction occurred. Using Naranjo's Assessment Scale to evaluate the association between lauromacrogol injection and anaphylactic shock， a score of 7 points was obtained， indicating a probable association. To date，there have been no published reports in domestic literature regarding adverse reactions associated with anaphylactic shock following administration of lauromacrogol injection. This article presents a case of anaphylactic shock with lauromacrogol injection，aiming to raise the awareness of medical professionals about the potential adverse reactions associated with lauromacrogol injection.

【Keywords 】Lauromacrogol injection; Anaphylactic shock; Esophagogastric variceal bleeding; Adverse drug reaction

聚桂醇注射液又名聚多卡醇、乙氧硬化醇，是一种清洁剂类血管硬化剂，临床上广泛应用于食管胃静脉曲张（gastroesophageal varices，GOV）、下肢静脉曲张、肝硬化门静脉高压并发食管胃静脉曲张破裂出血（esophagogastricvaricealbleeding，EVB）的止血治疗，还可用于治疗血管瘤、血管畸形、囊肿、痔等疾病[。（剩余10194字）