奥赛利定注射液用于术后镇痛的快速卫生技术评估

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【中图分类号】 R971+.2 【文献标识码】A

【Abstract】 Objective To evaluate the efficacy， safety and economy of oliceridine injection for postoperative analgesia by rapid health technology assessment （rHTA），and to provide evidencebased support for clinical decision-making. Methods PubMed， Embase， Cochrane Library， Web of Science，CNKI， WanFang Data， VIP databases and oficial websites of health technology assessment （HTA） institutions were electronically searched to collect HTA reports，systematic reviews/Meta-analysis， and pharmacoeconomic studies of oliceridine injection for postoperative analgesia from inception to April10，2025.Two reviewers independently screened the literature， extracted information and performed quality assessment of the included studies，and then summarized and comprehensively analyzed the results.Results A total of 4 articles were included，comprising 2 systematic reviews/Meta-analysis and 2 pharmacoeconomic studies.In terms of efficacy，the proportion of treatment responders and analgesic efect of oliceridine in treating patients were comparableto those of morphine.In terms of safety，compared with morphine，the incidences of adverse reactions such as nausea， vomiting，dizziness， pruritus，and respiratory adverse events caused by oliceridine were lower，and the diference was statistically significant （P<0.05） . In terms of economy， the use of oliceridine after surgery could efectively reduce total medical costs，and had more economic advantages compared to morphine. Conclusion Based on the current limited evidence，compared with morphine，oliceridine for postoperative analgesia has good effcacy，safety，and cost-effectiveness， but its economic benefits in China need further research.

【Keywords】Oliceridine; Postoperative analgesia; Efficacy; Safety; Economy; Rapid health technology assessment

术后疼痛是最常见的急性疼痛类型之一，超过 80% 的手术患者会经历此类疼痛，其中至少四分之三的患者疼痛程度达到中度至重度。（剩余15217字）