a2-肾上腺素受体激动剂治疗抽动障碍的研究进展
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【中图分类号】 R971+.93 【文献标识码】A
【Abstract】Tic disorder is a common neurodevelopmental disorder that develops in childhood，mainly characterized by motor and/or vocal tics.The treatment methods for tic disorders include both pharmacological and non-pharmacological interventions. q2 -adrenoceptor receptor agonists （including clonidine and guanfacine） are the first-line drugs for treating tic disorders， especially for mild to moderate tic disorders with comorbid attention-deficit hyperactivity disorder. Moreover， the usage of a2 -adrenoceptor receptor agonistshas been increasing year by year，and their rational use has attracted closed attention.To summarize the evidence regarding clinical efficacy and safety， this article systematically reviews the mechanism， pharmacokinetic and pharmacodynamic characteristics，and relative clinical researches of q2 -adrenoceptor receptor agonists in treating tic disorders. However，data quality， long-term efficacy monitoring，and genetic polymorphisms related to drug metabolism still have limitations，providing insights for further research.
【Keywords】Tic disorder; αa2 -adrenoceptor receptor agonists; Clonidine; Guanfacine
抽动障碍（ticdisorders，TD）是一种起病于儿童时期的神经系统发育障碍性疾病，需要进行全生命周期慢病管理。（剩余16086字）
