抗菌药物临床应用决策支持系统改善住院患者抗菌药物合理使用的成效分析

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中图分类号：R969.3文献标志码：A

Abstract Objective To analyze the improvement of antibacterial drugs rational use of inpatients by antibiotics clinical decision support system （aCDsS） in order to provide references for antimicrobial stewardship and rationaluse.MethodsThe aCDSS with knowledge base and rule engine was embedded in electronic medicalrecord （EMR）system to achieve a professonalreal-time supervision of antibacterial drugs medicalorders of entire process. These indicators ofantibiotic utilization rate and antibiotic use density（AUD），utilization rate and AUD of special grade antibacterial drugs，prophylactic utilization rate and rationalutilization rate of antibiotics during perioperative period n type Iincision surgeryand type II incision surgery in the hospital were compared between before and after aCDSS implementation.ResultsAfter aCDSS implementation， these indicators of antibiotic utilization rate （36.89%） ， AUD 34.78±1.35 ）DDDs， utilization rate （2.21%） andAUD 3.85±0.56 DDDs of special grade antibacterial drugs， prophylactic utilization rate （18.94%） ，rational course rate （95.93%） ，rational drug rate （99.21%） and total rational utilization rate （92.98%） ）of antibiotics during perioperative period in type I incision surgery， rational course rate（ （204号 90.25% ）， rational drug rate 97.46% ） and total rational utilization rate （86.44%） of antibiotics during perioperative period intype I incision surgery were improved compared with these before aCDsS implementation.There were significant differences in these indicators between before and after aCDSS implementation.ConclusionThe aCDsS canimprove therational use and these indicators of antibacterial drugs，and is an effective means ofantimicrobial stewardship.

Key wordsAntibacterial drugs;Special grade antibacterial drugs; Antibiotic use density;Antibiotic clinical decision support system; Rational use of drug; Prophylactic use of antibiotic

合理使用抗菌药物是提高疗效、减少药品不良反应以及延缓病原微生物耐药发生的关键。（剩余6097字）