穿心莲内酯调节IL-6/STAT3信号通路对急性心肌梗死大鼠心肌损伤的影响

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AbstractObjectieToinvestigateteefectofadrograpolidAndroonmyocadialinjuryinatsiacutemyocardlinfarctio Methods：RatAMmodelwasconstructedbyligatingtheleftanteriordescendingcoronaryartery（LAD），andtheratswererandomly assignedtotheshamsurgerygroup，modelgroup，low-，medium-ndhighdoseAndrogroups，andColivelingroup.Tecardiacfunction ofratswastested;2，，5ripenetrazoliuchlorideC）staningasapledtooseeteondionofmyocardialifarction. Hematoxylinandeosin（HE）stainingwasusedtoexaminepathologicalchangesinmyocardialtissue.Theassaykiswereusedtodetect lactatededi）di）i tumor necrosis factor- α（TNF-α） .Wester Blot was performed to detect the expression levels of IL-6，phosphorylated signal transducer and activatoroftrascrti3-）ndaltrascedactiatfrscritproteisinocadialtis Compared withthe shamsurgerygroup，the myocardialtissuedamage inthe model groupwassevere，theLVEDD，LVESD，LDH， infarctsize，CK-MB，cTnl，TNF- α ，IL-1β，IL-6，myocardial cellapoptosis rate，IL-6， p -STAT3/STAT3significantly increased，theLVFSand LVEF significantly decreased （P<0.05） ;Compared with the sham surgery group，the myocardial tissue damage in the model group was morsevere;e）e TNF- α ，IL-1β，IL-6，myocardial cellapoptosisrate，and p -STAT3/STAT3significantly increased，while leftventricularshort-axisejection fraction（LVEF），short-axisshorteningrate（LVFS） significantlydecreased（ P<0.05） .Compared with the model group，the myocardial injury in the low-，medium-，and high-dose Andro groups improved;theLVEDD，VESD，DH，infarct size，CK-MB，cnl，F- α⋅α ，IL-1β，IL-6，myocardial cell apoptosisrate，and p -STAT3/STAT3significantlydecreased，while theLVFSandLVEFsignificantly increased （P<0.05） .The STAT3 activatorColivelinevesedepotectivefctsofdroocadialinjuyonusioAdroanmpovemycaalinjuoe cardiacfunctiuaictitosdisatsdia of the IL-6/STAT3 pathway.

Keywordsacutemyocardialinfarction；myocardialinjuryandrographolide；interleukin-6；signaltransducersandactivatorsof transcription-3;experimental study

慢性心力衰竭（CHF）是常见的心血管疾病，对病人造成了重大的社会经济负担[。（剩余10220字）