化疗所致肠黏膜炎的病理机制和治疗策略研究进展

中图分类号R994.1；R979.1 文献标志码 A 文章编号 1001-0408（2025）17-2211-05

DOI 10.6039/j.issn.1001-0408.2025.17.22

Researchprogresson thepathological mechanismsand therapeuticstrategies of chemotherapy-induced intestinal mucositis

YAN Xiaochen，WANG Zongkui，YE Shengliang（Institute of Blood Transfusion，Chinese Academyof Medical Sciences，Chengdu ，China）

ABSTRACTIntestinal mucositisisa common complication inducedbychemotherapyin malignant tumors，which severely compromisestheeficacyofcemotherapyandreducespatients’qualityoflife.Thisarticlesystematicallyreviews thepathological mechanismsunderlyingchemotherapy-inducedintestialmucositisencompasingoxidativedamage，inflammatoryinjury，apoptotic damage，disruptinofteitesialbr，nditestialdysbsis.Aditioallitovdesompreensieummayft therapeuticstrategiesforintestinalmucositis，ncludingchemicalagentsandcompositematerials，naturalproducts，compound prescriptionoftraditional Chinesemedicine，growthfactors，bloodproducts，andfecal microbiotatransplantation.Futurefforts shouldstrengthenmultidisciplinarycro-innovation，integratinganimalmodelsandlarge-scalelinicaltrialstodevelopighly effective and low-toxicity therapeutic drugs that balance chemotherapy toxicity and antitumor efficacy.

KEYWORDSintestinal mucositis；chemotherapy；pathological mechanisms；therapeutic strategies；research progress

恶性肿瘤在全世界范围内呈现出较高的发病率与死亡率，严重威胁人类健康。（剩余15213字）