二甲双胍干预认知障碍相关疾病的作用机制研究进展

中图分类号R965 文献标志码A 文章编号 1001-0408（2025）15-1942-05

DOI 10.6039/j.issn.1001-0408.2025.15.22

Research progressonthemechanismof metformininthe interventionof cognitiveimpairment-related diseases

LIU Yuan1，²，XU Yumin1，2，3，LIU Shiyu1，²，YAN Huayu1，²，YANG Xin1，2 ，XU Hongcai1，²，WU Yabol，²（1. Dept.of Encephalopathy，the First Afiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003， China；2.The First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046， China;3.Henan Province Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine，Zhengzhou 450046，China）

ABSTRACTCognitiveimpairment（CI）isaclinicalsyndromecharacterizedbyprogresivedeclineinadvancedcognitive functionssuchasmemory，thinking，andjudgment.Itsetiologyandpathogenesis arecomplex，andthereiscurrentlyalackof specificdruginterventions.Metformin，asafirst-linehypoglycemicdrugfortype2diabetes，notonlylowersbloodglucoselevels but alsoimprovesCI.Thisarticlereviewsandsummarzes thepharmacological efectsand mechanismsof metformininimproving Alzheimer'sdisease，diabetescognitiveimpairment，cognitiveimpairmentafterchemotherapyinordertoprovidenovelisights andapproaches forthe treatmentofCI-relateddiseases.StudieshaveshownthatthemechanismbywhichMETintervenesinCI mainly includesregulating β -amyloid protein and tau protein metabolism，reducing insulin resistance，inhibiting neuroinflammation， improvingsynapticplastity，improvingmitochondrialdysfunction，regulatinggutmicrobiotaandlipidmetabolism，etc.Future researchneeds tobeconductedthrough interdisciplinarycollaboration，fullyintegratingmultipleomicsdata，andcombining advanced technologies to further reveal their mechanisms of effect.

KEYWORDSmetformin；cognitiveimpairment；Alzheimer’sdisease；diabetescognitiveimpairment；pharmacologicalaction; mechanism research

认知障碍（cognitive impairment，CI）是以认知功能下降为核心症状的获得性认知功能障碍综合征，主要包括神经退行性疾病如阿尔茨海默病（Alzheimer'sdisease，AD）和非神经退行性疾病如糖尿病认知障碍、化疗后CI、颅脑损伤及药物因素等诱发的认知损伤[。（剩余11957字）