伊朗分枝杆菌感染的案例报道及文献分析4

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中图分类号R915 文献标志码A 文章编号 1001-0408（2025）15-1931-05

DOI10.6039/j.issn.1001-0408.2025.15.20

Casereportand literatureanalysisofMycobacteriumiranicuminfection

ZHANG Yewen1，2，LUO Chengling'，JIANG Wengao’，CHEN Min，DU Qian4，YAO Wei3，LIU Songqing4，XI Xin4 （1.College of Pharmacy，Chongqing Medical University，Chongqing 401120，China；2.School of Basic Medicine and Clinical Pharmacy，China Pharmaceutical University，Nanjing 210oo0，China；3.Dept.of Respiratory Medicine，Third Afiliated Hospital of Chongqing Medical University，Chongqing 401120，China; 4.Dept.of Pharmacy，Third Afiliated Hospital of Chongqing Medical University，Chongqing 401120，China）

ABSTRACTOBJECTIVEToofferareference forthe treatmentofMycobacteriumiranicum infectionbyanalyzingthediagnosis and managementofasinglecasealongside literature-reportedcases.METHODSThroughcasereportandliteraturereviews，this studysynthesizedtheclinicalfeatures，therapeuticregimens，andpatientoutcomesofthoseinfectedwithM.iranicum.RESULS Inthesinglecasedocumentedinthisreport，subsequenttolinicalpharmacists’involvementintheconsultation，thepatientwas prescribed a therapeutic regimen comprising levofloxacin（ 0.5g ，qd，ivgtt） + Clarithromycin sustained-release tablets （ 1000mg ， qd，po） + Ethambutol tablets （ 0.75g ，qd，po）.The patient exhibited clinical improvement and was discharged after treatment. Thisarticle integrated12 published studies，encompassing 13 patients（7male and6 female），of whom 69.23% wereaged ⩾50 years.Patients infected with M. iranicum exhibited non-specific clinical manifestations and imaging features，with pulmonary infection as the primary presentation.Antimicrobial susceptibility test revealed that M. iranicum was susceptible to multiple agents， includingamikacin，clarithromycin，linezolid，andethambutol.Thethre-drugcombinationtherapywasthemostfrequently employed regimen. In terms of clinical outcomes，there were 9 cases（ 69.23% ）of clinical cure，3 cases （23.08% ）of bacteriological negativity conversion，and 1 case（ 7.69% ）of treatment failure. CONCLUSIONS For M. iranicum infection，a triple-drugtherapeuticregimenconsistingof threeagentswithdistinct mechanismsofactionselectedfromamikacin，

clarithromycin， moxifloxacin，levofloxacin，minocycline， ethambutol， and otherrelevant drugsmayrepresenta relativelyoptimal strategy.

KEYWORDSMycobacterium iranicum; nontuberculous mycobacteria；pharmacotherapy；literaturereview

随着细菌分离鉴定技术的不断进步，新的非结核分枝杆菌（nontuberculousmycobacteria，NTM）菌种不断被发现。（剩余8615字）