基于循证方法学和德尔菲法构建地佐辛注射液的药物利用评价标准

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中图分类号R95 文献标志码A 文章编号 1001-0408（2025）15-1841-05

DOI 10.6039/j.issn.1001-0408.2025.15.04

Construction of drug utilization evaluation criteria for Dezocine injection based on evidence-based methodology and Delphi method

GUO Yuanyuan，WANG Chao，QIN Yinpeng，ZHANG Yi，BU Yishan（Dept. of Pharmacy， Tianjin First CentralHospital，Tianjin ，China）

ABSTRACTOBJECTIVEToconstructthedrugutilization evaluationcriteriaforDezocine injection，soas toprovidereference fortherational druguseinmedical institutions.METHODSOnthebasisofevidence methodology，relevant guidelines/expert consensus，systematicreviews/meta-analysiswereconsulted；theevaluationcriteriaframeworkforDezocineinjectionwas establishedafterscrenngevidence.Delphi methodwasemployed，whereby28cliniciansandclinical pharmacistsfromscodary andabove-levelmedicalinstitutionsacrosseightprovinces，ncludingTianjin，BeijingandShandong，wereselectedtoparticipate intworoundsofquestionnairesurveys.Thefinalindicatorsweredeterminedbasedontheexperts’enthusiasmcoficient，authority coefficient，and degree of coordination.RESULTS The effective recovery rate of questionnaire was 100% in the first round and 92.86% inthesecondround;expertauthoritycoeficient wasO.82inthefirstroundandO.81inthesecondround;thecoordination degree of experts in the first round was O.29，and in the second round was 0.31（ P<0.001 ）.Drug utilization evaluation standard systemforDezocineinjectionwasformedfinally，includingthreedimensionsof medicationindications，medicationprocessand medicationresults，withatotalof1frst-levelindicators（suchasindications，usageanddosage）and33second-levelindicators （such aslaboranalgesiaandthe managementof severepain folowing majoror moderatesurgeries combined withother analgesic drugs）.Theaverageimportancescores foreachindicatorrangedfrom408to5.00points，withanoverallaveragescoreof4.61 pointsadcoefficientofvariationrangingfromOtoO.19.CONCLUsIONSThedrugutlizationevaluationcriteriaforDezocine injectionestablishedbasedonevidence-basedmethodologyandDelphimethodisauthoriativeandscientific，whichprovidesa reference for subsequent evaluation of the rationality of clinical medication.

KEYWORDsDezocine injection；drug utilization；evaluation criteria；evidence-based methodology；Delphi method

地佐辛注射液作为新型的阿片受体激动-拮抗剂，被广泛应用于中小手术术后镇痛及多模式联合镇痛。（剩余7416字）