Wnt/β-catenin与胰腺癌早期转移相关性的研究进展

【摘 要】胰腺癌是起源于胰腺的恶性肿瘤，生存率极低，复发率极高，严重影响患者生命质量。胰腺癌较早出现转移，早期诊断较困难，化疗过程易出现化学耐药。Wnt信号通路与胰腺癌迁移、侵袭、转移有关。本文综述了Wnt信号通路及其与癌症及胰腺癌侵袭和转移的关系，以期为胰腺癌的治疗和控制寻找新的突破口。

【关键词】Wnt/β-catenin信号通路；胰腺癌；远处转移

中图分类号：R735.9 文献标识码：A 文章编号：1004-4949（2022）19-0101-03

Research Progress on the Correlation Between Wnt/β-catenin and Early Metastasis of Pancreatic Cancer

GUO Bin-bin1， NAN Jin-niang1， XU Wen-peng2

（1.Department of Clinical Medicine， Nanchang Medical College/Jiangxi Health Vocational College， Nanchang 330052， Jiangxi， China； 2. Department of Encephalopathy， Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine， Nanchang 330006， Jiangxi， China）

【Abstract】Pancreatic cancer is a malignant tumor originated from the pancreas， with extremely low survival rate and high recurrence rate， which seriously affects the quality of life of patients. Pancreatic cancer has early metastasis， early diagnosis is difficult， and chemotherapy is prone to chemical resistance. Wnt signaling pathway is related to migration， invasion and metastasis of pancreatic cancer. This article reviews the Wnt signaling pathway and its relationship with cancer and pancreatic cancer invasion and metastasis， in order to find a new breakthrough for the treatment and control of pancreatic cancer.

【Key words】Wnt/β-catenin signaling pathway； Pancreatic cancer； Distant metastasis

胰腺癌（pancreatic cancer）是预后最差的恶性肿瘤之一，发病率逐年上升，5年生存率低于8%，复发率高达75%～90%[1]。（剩余5362字）