基于网络药理学探讨名医秦国政教授秦氏四妙散的作用机制
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中图分类号：R697.33 文献标志码：A 文章编号：1007-2349（2025）08-0026-07
【Abstract】Objective：To explore the possible mechanism of action of“Qin’s Four Wonders Powder”byPrfessor Qin Guozheng inthe treatment of chronic prostatitisby using network pharmacology.Methods：Herbal active ingredientsandtargets were colected by TCMSP，andthe“herb-active ingredient-target”network diagram was constructedusing Cytoscape3.8.O.Disease-related targets were retrieved with the keyword“chronic prostatitis” in multiple databases such as OMIM，Genecards，and Drugbank.ThePPI network graph was obtained using the String database and topological analysis was conducted.GO and KEGG enrichment analyses was performed，and R4.0.3 software was used to draw bubblechartsand bar charts.Results： Qin’s Four Wonders Powder containeda total of144 active ingredients，with138 potential targets.Eleven core targets such as MAPK1，TP53，and STAT3 could be screened out.A total of 2，645GOenrichment results were obtained.The KEGG results involved179 signaling pathways.Theresults of network pharmacological analysis showed that quercetin，kaempferol，glycyrhizin A，naringin，etc.were the main active ingredients of Qin's Four Wondwrs Powder，while STAT3，TP53，MAPK1，etc.were the main targets of Qin's Four Wonders Powder inthe treatmentof chronic prostatis.Thecommon targets were enriched in multiple signaling pathways such as the PI3K -Akt signaling pathway，the AGE -RAGE signaling pathway，the IL -17 signaling pathway， andthe TNFsignaling pathwayand regulating biological proceses such ascells，apoptosis，and gene transcription. Conclusion：This study expounded the action mechanism of“multiple components，multiple pathways，and multiple targets”ofQin'sFour Wonders Powderin the treatment of chronic prostatitis，providing acertaintheoretical basis and reference for further understanding the mechanism of action of Qin's Four Wonders Powder and exploring new clinical applications and experimental research.
【Key words】Network Pharmacology； Qin's Four Wonders Powder； Chronic Prostatitis；Mechanism of Action
慢性前列腺炎（chronicprostatitis，CP）是一种临床表现为下腹及会阴等部位隐痛不适、出现排尿异常的生殖系统疾病[1]，部分患者还伴有焦虑、抑郁、恐惧等精神心理障碍以及勃起功能障碍、早泄等性功能障碍，严重影响患者的身心健康和生活质量，并加重社会经济负担[2]。（剩余8277字）
