脂联素联合FGF21与高血压患者冠脉钙化积分的相关性研究

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中图分类号：R541.4 文献标志码：A DOI ： 10.3969/j .issn.1003-1383.2025.06.003

Study on correlation between adiponectin combined with FGF21 and coronary artery calcification score in hypertensive patients

LI Kela，CEN Tuan， PAN Zheng （Department of Cardiovascular Medicine，Affliated Hospital of Youjiang Medical Universityfor Nationalities，Baise533Ooo，Guangxi，China）

【Abstract】ObjectiveToexplore theexpresioncharacteristicsof serumadiponectinandfibroblastgrowth factor 21 （FGF21）inhypertensioncombined with coronaryarterycalcificationandtheircorelation withcalcificationscore bydetecting theexpressionlevelsof thesetwofactorsinhypertensivepatients withcoronaryarterycalcification.Methods46patients with primaryhypertensioncombinedwithcoronaryarterycalcificationwereselectedasexperimentalgroup，and42patientswith hypertension without coronaryartery calcification wereselectedas control group.Fasting blood was drawn todetectserum homocysteine，lipids，uricacid，C-reactive protein，andfasting bloodglucosebyalargebiochemicaldetector，andcoronary artery calcification wasexaminedandscoredbychest CT.The levelsof serumadiponectinandFGF21 were detected by enzym-linked immunosorbentassy（ELISA），andtheircorrelationwithcoronaryarterycalcificationscorewereanalyzed. ResultsCompared with thecontrol group，the experimental grouphadasignificant decreaseinadiponectin（2.75[2.33， 3.07lmg/L vs 3.01⌊2.66，3.15⌋mg/L，P=0.042） ，a significant increase in FGF21（ 102.39⌊92.28，116.58⌋pg/mL vs 95.17‰ ，and a significant decrease in the ratio of adiponectin to FGF21 （0.03[0.02，0.03] VS 0.03[0.03，0.04] ， P=0.004 ）.Adiponectin was negatively correlated with coronary artery calcification score （ r=-0.317 P=0.032 ），while FGF21 was positively correlated with coronary artery calcification score （ r=0.349 ， P=0.017 ）. Conclusion AdiponectinandFGF21maybeinvolvedinthepathogenesisofcoronaryarterycalcificationinhypertension，andtheimbalance ofFGF21 maybea driving factorfor coronary artery calcification in hypertension.

高血压是冠状动脉钙化（coronaryarterycalcifi-cation，CAC）的独立促进因素，而CAC作为动脉粥样硬化的晚期表现，不仅是斑块负荷的标志，更是心血管事件和全因死亡的强预测因子[1]。（剩余7926字）