非高密度脂蛋白/高密度脂蛋白比值与胆囊息肉样病变的关联性分析：一项回顾性横断面研究

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【关键词】胆囊息肉样病变;危险因素;非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值

中图分类号：R575.6 文献标志码：A DOI ：10.3969/j . issn.1003-1383.2025.04.009

Association analysis of non-high density lipoprotein/high density lipoprotein ratio with polypoid lesions of gallbladder ： a retrospective cross-sectional study

BAI Rui'，ZHAO Yunfei 2 ，LU Huanhuan’，CHANG Yuwen' （1.Health Management Center，People's Hospitalof Xinjiang Uygur AutonomousRegion， Urumqi 83o，Xinjiang，China; DepartmentofOncologytheourthClinicalMedicalCollgeofXinjiang MedicalUniversity，Urumqi83oo，Xinjiang，China）

【Abstract】ObjectiveToinvestigateassociationbetwen thenon-high density lipoproteincholesterol（non-HDL-C）/high densitylipoproteincholesterol（HDL-C）ratioandpolypoidlesionsof galbladder（PLG）.MethodsAretrospectiveanalysis wasconductedon476O7individualswho underwent healthcheck-upsat theHealth Management Centerof thePeople's Hospital of Xinjiang UygurAutonomousRegionfrom March 2O22 toApril2O23Afterultrasounddiagnosis，theparticipantsweredivided intoPLGgroupandnon-PLG group.Andthen，generalinformationandlaboratory indicatorsofthetwo groupswerecompared andanalyzed.Multivariable binarylogisticregressionanalysis wasusedtoevaluatethe associatedriskfactorsforPLG.Results The results of the single-factor analysis showed that in the PLG group，the proportion of individuals aged > 29 to <50 years， males，essentialhypertension，type2diabetes，hroiccholecystitis，ndfattliver，aswellasM，werehigherthanthosein the non-PLG group.In contrast，，the proportion of individuals aged ⩽ 29 years and ⩾50 years，females，coronary heart disease，and galstones was lowerin thePLG groupthan inthe non-PLGgroup，so differences were statisticallysignificant（ P< 0.05）.In the PLG group，DBP，SUA，TC，TG，LDL-C，and non-HDL-C/HDL-C were higherthan thoseinthe non-PLG group （ P<0.05 ），while HDL-C was lower than that in the non-PLG group （ P<0.05 ）.The logistic regression analysis showed that the non-HDL-C/HDL-C ratio （ OR=1 .151， 95% CI：1.O18＼～1.303）was significantly positively correlated with PLG（ P<

0.05）.ConclusionThenon-HDL-C/HDL-CratioisanindependentriskfactorforPLG.Each increaseof1unitinthenonHDL-C/HDL-C ratio increases the risk of gallbladder polypoid lesions by 15.1%

【Keywords】polypoid lesions of gallbladder（PLG）；risk factor;non-high density lipoprotein/high density lipoproteinratio

当今人们的生活方式、饮食结构随着社会经济的快速发展早已发生了转变，高脂肪及高蛋白食物摄入增多，导致血脂相关指标异常的检出率呈现逐年上升趋势，肥胖人群也不断增加[1]。（剩余11060字）