钦州市无偿献血者人类嗜T淋巴细胞病毒感染状况调查

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中图分类号：R457.1；R446.6 文献标志码：A DOI：10.3969/j. issn.1003-1383.2025.04.008

Investigationon human T-lymphotropicvirusinfection among voluntary blood donors in Qinzhou City

WEI Lilian，YUAN Xiaoying，XIE Lanqian，LAN Jun，HUANG Dong，CHEN Bochang（Department of Clinical Laboratory，Qinzhou Central Blood Station，Qinzhou 535000，Guangxi，China）

【Abstract】ObjectiveTo investigate the infection conditionofhuman T-cellymphotropic virus（HTLV）among voluntaryblooddonors in Qinzhou City，soasto provideabasis forformulating blood screning strategiesin China.MethodsA totalof74716bloodsamples werecolectedfromvoluntaryblooddonorsinQinzhou CityfromJuly2022 toMay2024.The antibodies against HTLV-1/2 weredetectedbydouble-antigensandwich enzyme-linked immunosorbentassy（ELISA）Samples thatshowedreactivityweresenttothe Guangxi Blood Center forfurtherconfirmationbyWesternblot（WB）andrealtimefluorescent quantitativepolymerasechainreaction（PCR）．ResultsAmongthe74716blood donorsamplestested by ELISA，10 cases were positive for HTLV-1/2 antibodies，with a preliminary sreening positivity rate of O .134‰ ；among the 10 initiallyscreened positiveblooddonors，onecase wasconfirmedtobepositiveforHTLV-1，withaconfirmed positivity rate of 0.0134%o ，no HTLV-2 positive blood donors were detected，and the confirmed positive donor was a Han Chinese of Qinzhou native.ConclusionCurrntly，there isno HTLV-2 infection detectedamong voluntary blood donorsinQinzhou City.However，alow level of HTLV-1infection，mainlyamong local residents，doesexist.Continuousmonitoring istil neded.Toensure bloodsafety，efectivepreventiveandcontrol measuresshouldbetakentoreducetheriskofHTLVtransmission through blood.

【KeyWords】human T-cellymphotropic virus （HTLV）；voluntary blood donation；infection condition

人类嗜T淋巴细胞病毒（humanT-celllympho-tropicvirus，HTLV）于20世纪80年代初被发现，是迄今为止第一个被发现与癌症相关的RNA逆转录病毒，可引起成人T细胞白血病/淋巴瘤（adultT-cellleukemia，ATL）热带痉挛性下肢轻瘫/HTLV-1相关性脊髓病（tropical spastiparaparesis/HTLV-1 associatedmyelopathy，TSP/HAM）、下肢瘫痪等疾病，严重者可以导致死亡[1-3]。（剩余7212字）