基于孟德尔随机化法探究宫颈(阴道)分泌物异常与胎膜早破的因果关系

打开文本图片集

中图分类号：R714.2 文献标志码：A DOI： 10.3969/j .issn.1003-1383.2025.04.005

Exploration of causal relationship between abnormal cervical （vaginal） discharge and preterm premature rupture of membranes based on Mendelian randomization

（1.The First Clinical Collge of Guizhou University of Traditional Chinese Medicine，Guiyang 550025， Guizhou，China；2.Department of Obstetrics，theFirst Affiliated Hospital of Guizhou University ofTraditional ChineseMedicine，Guiyang55ooo1，Guizhou，China）

【Abstract】ObjectiveTo explorecausal relationship betweenabnormalcervical（vaginal）secretionand premature rupture of membranes（PROM） by Mendelian randomization（MR）.MethodsSingle nucleotide polymorphisms（SNPs）in GWAS database were used as instrumental variables（IV），and P values in the inverse variance weighted（IVW）were used as main basisforestimatingbidirectionalcausalitybetweenabnormalcervical（vaginal）dischargeandPROM.Sensitivityanalysiswas usedtoevaluatetherobustnessof theanalysisresults.ResultsTherewasacausal relationshipbetweenabnormal cervical （vaginal） discharge and PROM（ OR=1 . 124， 95% CI=1.041--1.213 ： P=0.002 ）.In reverse MR analysis，PROMhad a causal relationship with abnormal cervical（vaginal）discharge（ OR=1.037 ，95 % CI=1.004-1.071 ， P=0.028 ）． The resultsofsensitivityanalysiswererobust，andtherewasnohorizontal pleiotropyand heterogeneityamong the SNPS.ConclusionThere is a bidirectional causal relationship between abnormal cervical （vaginal） discharge and PROM.

【Keywords】abnormal cervical（vaginal）discharge；premature rupture of membranes （PROM）；Mendelianrandomization（MR）；causal relationship

胎膜早 破（premature rupture of membranes，PROM）是指临产前胎膜发生自然破裂[1]，可由多种因素综合作用所导致，如营养缺乏、炎症细胞因子的影响、氧化应激等。（剩余6842字）