替罗非班桥接阿替普酶静脉溶栓治疗进展性急性缺血性脑卒中的临床疗效

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中图分类号：R743.3 文献标志码：A DOI ： 10.3969/j .issn.1003-1383.2025.04.007

Efficacy of tirofiban bridging with alteplase for intravenous thrombolysis in the treatment of progressive acute ischemic stroke

（1a.Department of Neurology，1b. Department of Otolaryngology，1. The Second Hospital of Sanming

City，Yong'an366Ooo，Fujian，China；2.Academician and ExpertWorkstation，FujianPolytechnic ofWaterConservancy and Electric Power，Yong'an 366Ooo，Fujian，China）

【Abstract】ObjectiveToinvestigatethesafetyandefficacyoftirofibanbridging withalteplaseforintravenous thrombolysisinthetreatmentof progressiveacuteischemicstroke（AIS）.MethodsAtotalof76patientswith progressiveAISadmitted tothe Departmentof Neurology atthe Second Hospital of Sanming Cityfrom February 2O21toFebruary2O24 were selectedandrandomlydivided into control groupandobservation group，with38cases ineach group.Thecontrol group were given intravenousthrombolysiswithalteplase，whiletheobservationgroupweregiventirofiban bridging therapyafteralteplase thrombolysis.Andthen，theNational Institutes of Health Stroke Scale（NIHSS）scores at14 daysafterthrombolysis，the activitiesofdailyliving（ADL）andmodifiedRankinscale（mRS）scoresat9Odaysaswellasclinicaleficacy，hospitalizationtime，and theoccurrenceof drug reactions werecomparedbetwen thetwo groups.ResultsTheNIHSSscore inthe observation group was lower than that in the control group at 14 days after thrombolysis （ P<0.05 ），the mRS score in the observation group was lower than that in the control group after 9O days of follow-up （ P<0.001 ），and the ADL score was higher than that in the control group（ P<0.001 ）.The total effective rate in the observation group was higher than that in the control group （ （P<0.01 ），and the hospitalization duration was shorter than that in the control group （ P<0.001 ）. One case of intracranial hemorrhage andonecaseof systemic bleeding occurredin each group，andnootherobviousadversereactions were observed.ConclusionFor patients with progressiveAIS，when symptoms worsen afterintravenous thrombolysis with alteplase，theuseoftirofiban bridging therapywithin2-12hourscanimprove neurologicalfunction，enhancedailyliving ability，reduce disability，shorten hospitalization time，with definite clinical eficacy and good safety.

【Keywords】tirofiban；alteplase；progressive acute ischemic stroke（AIS）；safety

我国是脑卒中大国，据最新统计，我国每年新发脑卒中人数达394万人，并且正以每年 8.7% 的速度上升[1]。（剩余6532字）