初产妇子痫前期发病危险因素的Meta分析

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作者简介 陈婉红，主治医师，本科，E-mail：7737783@qq.com

引用信息 陈婉红.初产妇子痫前期发病危险因素的Meta分析［J］.循证护理，2025，11（1）：19-23.

Abstract Objective：To evaluate the risk factors for preeclampsia in primiparas.Methods：Literature on risk factors for preeclampsia in primiparas was retrieved from domestic and foreign databases，and Meta⁃analysis was performed.The robustness of the results was verified by sensitivity analysis，and the Egger's test was used for the publication bias test.Results：A total of 15 articles were included，involving 3 093 792 primiparas in preeclampsia.Meta⁃analysis results showed that hypertension（OR=2.775，95%CI 1.164⁃6.617），diabetes（OR=2.650，95%CI 1.280⁃5.487），age（OR=1.512，95%CI 1.069⁃2.139），BMI（OR=1.949，95%CI 1.497⁃2.537），organic heart disease（OR=2.568，95%CI 2.013⁃3.276） were risk factors for preeclampsia in primiparas；drinking（OR=0.556，95%CI 0.351⁃0.882） and smoking（OR=0.734，95%CI 0.606⁃0.889） were protective factors for preeclampsia in primiparas.Egger's test showed that the literature included the BMI index had publication bias（t=2.69，P=0.025）.Conclusions：Current evidence shows that hypertension，diabetes，age，and organic heart disease are definite risk factors for the onset of preeclampsia in primiparas.

Keywords  primiparas；preeclampsia；risk factors；Meta⁃analysis；evidence⁃based nursing

摘要  目的：评价初产妇子痫前期发病的危险因素。（剩余8270字）