特定溶质载体蛋白相关基因对预测胃癌预后及其增殖、迁移和侵袭的影响

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中图分类号：R735.2 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.04.010

Effects of Solute Carrier Protein-associated Genes on Gastric Cancer Prognosis Prediction and Their Influence on Proliferation， Migration， andInvasion

YANGYanqing，CHENSong，LILi （Xuzhou MedicalUniversity，Xuzhou2210oO，China）

Abstract： Bioinformaticsanalysis-basedconstructionofaprognosticprediction modeltoinvestigate therelationshipbetween specific solute carier protein （SLC）-related genes and gastriccancer （GC）in immunityand prognosis.RNA sequencing and clinical data were downloaded fromthe cancer genome atlas （TCGA）and gene expressonomnibus （GEO）databases. Diferential expressionofSLC-related geneswas extractedusingRsoftware.UnivariateandmultivariateCoxregression analyses were employed to constructarisk prediction model for GC prognosis basedon SLC-related genes closely associated with survival.The prognostic performance of the model was validated through Kaplan-Meier survivalanalysis，regression analysis，andreceiveroperatingcharacteristic （ROC）curves.Correlationsbetweeriskscoresandimmune-infiltratingcels， tumorimmune microenvironment，andclinical features were assessed.The impactofSLC43A3 knockdownon theproliferation andmigrationofBGC-823cellswas evaluatedvia CCK-8，scratch wound healing，andTranswellassays.Atotalof115 diferentialyexpressed SLC-related genes were identified，with14 genes inked toprognosis.Eight genes wereselectedto establishtheprognosticriskscoring model.TheSLC-relatedgeneprognosticmodeldemonstrateshigh predictivevalueand is significantlyasociatedwithheterogeneityinimmunecellinfiltration，providingimportantreferencesforpersoalized medicationinGCpatients.Functional experiments revealedthatSLC43A3significantlypromotestheproliferation，migration， andinvasionofgastriccancercells.ThisstudymaysuggestnoveltherapeutictargetsforGCtargetedtherapyresearch.

KeyWords：gastriccancer;specificsolutecarrier protein; prognostic model; immune reaction;bioinformatics

（ActaLaserBiology Sinica，2025，34（4）：374-384）

胃癌（gastriccancer，GC）是全球常见的恶性肿瘤之一，严重威胁着人类的生命健康。（剩余16697字）