主动冷却对 808nm 激光经颅照射小鼠头皮和下颌温度的影响

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中图分类号：Q631 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.04.004

Effects of Active Cooling on Scalp and Jaw Temperature in Mice Irradiated by 808nm Laser

WANGJinglan’，LIUYilin²，HURuixin²，LIUJnjun²，CAOLei，ONGXiaowei³，ULiyue³，WNGYu （1.TheecondClincalMedicalCollegeofhaanxiUniversityofCineseMedicine，Xianyang7246，China;2.Department ofPhysiologyandPathophysiologySchoolofasic Medicine，Xi'anJiaotong University，Xi'an7Oo61，China;3.Xian BluerayMedicalchnologies，LD.，Xi'an7O11，China;4.epartmentofnesthesiaurgery，Xiayangentralopitalo Shaanxi Province，Xianyang 712Ooo，China）

Abstract：To evaluate the thermalsafetyoftranscranial photobiomodulation，thisstudy investigates theeffectsof 808nm laser irradiationonscalpandmandibular temperatures，aswellassafetyparameters，whenappiedtotheheadsoflive mice under varying iluminationdurationsand powerlevels.Aditionally，toevaluate whethera water-cooling devicecanefectively reduce irradiation-iducedtemperature increases.The8O8nmlaserwas directedatthefontanellofmice.Scalptemperatures were measuredusinganinfraredthermal imager，andjawtemperatures wererecordedusingathermocouple.C57BL/6Jmice were divided into threegroups： GroupA（natural coling）， GoupB（active cooling），and GroupC（negative control）. Group

A was further subdivided into A， A2， and A3 based on different power levels of irradiation. Changes in scalp and mandibular temperatures were recorded at an irradiation dose of ～140J Scalp temperature increased by 4.2% in Group A and by 2.4qC in Group B， with Group B showing a temperature reduction of 1.8qC compared to the corresponding power level in Group A. Jaw temperature measurements indicated a rise of 3.0qC in Group A and 2.4cC in Group B. As the average power of the 808nm laser increased，local temperatures rose significantly.Anaverage irradiation power of approximately 300mW and a dose of ～140J werefoudtobesafeformouse transcranial irradiation.Forhigher powerlevels，activecooling effectivelymitigated local temperature increases.Theresultsofthis studycanprovide experimentalbasis forsettingtheparameterrangeoftranscranial irradiation in mice.

Key words： 808nm laser; exposure dose; mice; transcranial irradiation; photobiomodulation （ActaLaser Biology Sinica，2025，34（4）：312-318）

光生物调节（photobiomodulation，PBM）是一种利用低强度光能的非侵入性治疗技术。（剩余11955字）