肠道菌群与肾细胞癌关系的孟德尔随机化分析

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ABSTRACT：ObjectiveTo explore the correlation between gut microbiota and renal cell carcinoma （RCC） with Mendelian randomization analysis.MethodsData involved with genome-wide association of the gut microbiome were retrieved from MiBioGen Consortium as the exposure group data，and RCC data were obtained from the FinnGen GWAS database.Next，a rigorous Mendelian randomization analysis was conducted utilizing multiple methods，including inverse variance weighted （IVW），MR-Egger，maximum likelihood，and weighted median.Additionally，sensitivity analysis was performed to address heterogeneity and horizontal pleiotropy concerns.ResultsA total of2564 single nucleotide polymorphisms （SNPs） from the complete gut microbiota were analyzed.IVW analysis showed that bacillus （OR=0.780，95%CI：0.614-0.991，P=0.042） and anaerobic bacillus （OR=0.723，95%CI：0.533-0.981，P=0.037） reduced the risk of RCC.Actinomycetes （OR=1.302，95%CI：1.015-1.672，P=0.038），family Ⅺ （OR=1.197，95%CI： 1.023-1.400，P=0.024），coprococcus 2 genera （OR=1.440，95%CI：1.046-1.982，P=0.026），clostridium lactate （OR=1.732，95%CI：1.254-2.392，P=0.001） and Odoribacter （OR=1.685，95%CI：1.150-2.469，P=0.007） were associated with an increased risk of RCC.Sensitivity analysis did not identify any abnormal SNPs，indicating the robustness and  reliability of our findings.ConclusionThere may be a cause-and-effect relationship between different types of gut microbiota andgenetically predited renal cell carcinoma，and different microbiota may be respectively associated with an increase or decrease in RCC.

摘要：

目的采用孟德尔随机化分析探索肠道菌群组成与肾细胞癌（RCC）之间的因果关系。（剩余7877字）