腹腔镜膀胱癌根治术中采用吲哚菁绿荧光显像与标准淋巴结清扫临床疗效的随机对比研究

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ABSTRACT：ObjectiveTo investigate the efficacy，safety and feasibility of regional lymph node dissection in laparoscopic radical surgery for bladder cancer under the guidance of indocyanine green fluorescence imaging.MethodsA total of 30 patients with muscle invasive bladder cancer （T2/T3NxM0） who volunteered to enter the clinical trial were randomly divided into the indocyanine green imaging guided laparoscopic regional lymph node dissection group （n=15） and the standard pelvic lymph node dissection group （n=15）.The number of positive lymph nodes，operation time，intraoperative bleeding volume，incidence of lymph leakage，and tumor recurrence and metastasis rate 2-year after surgery were collected.ResultsThe number of positive lymph nodes was （4.20±1.66） and （4.60±1.72） respectively in the indocyanine green and standard groups，with no statistically significant difference （P>0.05）.There were no statistically significant difference in the tumor recurrence and metastasis rates 2-year after surgerybetween the two groups （P>0.05）.However，the indocyanine green group had shorter operation time，less intraoperative bleeding volume，and lower incidence of lymphatic leakage than the standard group （P<0.05）.ConclusionIndocyanine green fluorescence imaging guided laparoscopic lymph node dissection has comparable clinical efficacy to standard lymph node dissection，but with fewer complications.

摘要：目的探讨吲哚菁绿荧光显像引导下腹腔镜膀胱癌根治术中区域淋巴结清扫的有效性、安全性及可行性。（剩余6061字）