膀胱癌靶向药物的新载体：金属纳米粒子

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A new carrier of targeted drugs for bladder cancer：metal nanoparticles

YU Xiao1，XU Shenghan2，3，CHEN Bo1，WANG Qiang1

（1.Department of Urology，The Affiliated Hospital of Guizhou Medical University，Guiyang 550004;2.Department of Urology，Liupanshui Peoples Hospital，Liupanshui 553000; 3.Department of Urology，The Affiliated Hospital of Changchun University of Chinese Medicine，Changchun 130021，China）

ABSTRACT：The current clinical treatment of bladder cancer （BCa） is mainly surgical treatment，supplemented by postoperative chemotherapy and immunotherapy.However，due to the lack of specificity，targeting and other reasons，the therapeutic effect is not satisfactory.In recent years，it has been found that metal nanoparticles （MNPs） prepared by gold，silver，and so on，as bladder infusion drugs or drug carriers，can not only accurately target BCa cells，but also have high stability and drug release rate，thereby reducing the side-effects of chemotherapy drugs.Based on domestic and foreign studies，this paper reviews the progress of MNPs in the treatment of BCa，including gold，silver，copper and other MNPs，and prospects the trend of bladder perfusion combined with nanomedical drugs.

KEY WORDS：bladder cancer;targeted therapy;nanoparticles;metal nanoparticles;photodynamics therapy;immunotherapy

摘要：膀胱癌（BCa）目前临床上的治疗以手术为主，并辅以术后化疗、免疫治疗等。（剩余16703字）