骶神经调控治疗顽固性间质性膀胱炎/膀胱疼痛综合征的有效性及安全性

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Efficacy and safety of sacral neuromodulation in the treatment of refractory interstitial cystitis/bladder pain syndrome

ZHENG Qiangping，ZHANG Jianzhong，WANG Fei，ZHANG Chaohua，ZHANG Peng

（Department of Urology，Beijing Chaoyang Hospital，Capital Medical University，Beijing 100020，China）

ABSTRACT：Objective To summarize the long-term efficacy and safety of sacral neuromodulation （SNM） in treating refractory interstitial cystitis/bladder pain syndrome （IC/BPS），so as to provide clinical evidence for this therapeutic approach.Methods This study retrospectively analyzed the data of 27 patients with refractory IC/BPS treated at our hospital during Jan.2015 and Dec.2021.All patients underwent SNM Ⅱ.The therapeutic effects were evaluated with Global Response Assessment （GRA）.The preoperative and postoperative daily urinary frequency，nocturia frequency，functional bladder capacity，OLeary-Sant score，pelvic pain，urgency and frequency （PUF） score，quality of life （QoL） score，and visual analogue scale （VAS） score were compared.Results During the follow-up of （55.55±16.33） months，12 patients showed no symptom relief （GRA≤4），while 15 experienced symptom relief （GRA>4），resulting in an efficacy rate of 55.56% （15/27）.The average daily urination frequency decreased from （28.74±13.84） to （24.74±16.33） times，the OLeary-Sant score decreased from （30.19±5.35） to （25.63±9.34），PUF score decreased from （25.63±5.34） to （22.04±8.29），QoL score decreased from （5.67±0.55） to （4.33±1.57），and VAS score decreased from （8.04±1.91） to （5.33±3.09），the differences were statistically significant （P＜0.05）.No complications such as incision infections or pain at the implant site were observed.Conclusion SNM is safe and effective for refractory IC/BPS，but there is a risk of long-term failure.Therefore，patients should be discreetly selected.

KEY WORDS：sacral neuromodulation; interstitial cystitis; bladder pain syndrome

摘要：目的 分析骶神经调控（SNM）治疗顽固性间质性膀胱炎/膀胱疼痛综合征（IC/BPS）的长期疗效及安全性，为该疾病的诊治提供更多临床证据。（剩余9229字）