局灶射频消融治疗低危与中危局限性前列腺癌的疗效分析

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Efficacy of focal radiofrequency ablation in the treatment of low-to-intermediate risk localized prostate cancer

GAO Shu，JIANG Zhen，SUN Jiyuan，HUANG Haifeng，ZHANG Qing，GUO Hongqian

（Department of Urology，Nanjing Drum Tower Hospital，Affiliated Hospital of Medical School，Nanjing University，Nanjing 210000，China）

ABSTRACT：Objective To explore the efficacy of focal radiofrequency ablation （RFA） in the treatment of low-to-intermediate risk localized prostate cancer and its impact on postoperative urinary control and sexual function recovery，in order to explore the feasibility of minimally invasive methods for the treatment of localized prostate cancer.Methods Clinical data of 28 patients with low-to-intermediate risk localized prostate cancer who underwent RFA in Nanjing Drum Tower Hospital，Affiliated Hospital of Medical School during Jun.2017 and Feb.2021 were retrospectively analyzed.The 5-year failure-free survival （FFS） rate，surgery related complications，postoperative urinary control and sexual function were collected.The differences between the survival curves of patients in the low-risk and intermediate-risk subgroups were assessed with log-rank test and Breslow test.Results All surgeries were successfully completed under local anesthesia.During the median follow-up of 43 （40-49） months，the 5-year FFS rate predicted by Kaplan-Meier method was 78.57%; 25 patients （89.29%） did not experience surgery-related complications; 27 patients （96.43%） were able to control urination; 1 patient developed new-onset sexual dysfunction.There was no significant difference in the survival curves between patients in the low-risk and intermediate-risk groups （P＞0.05）.Conclusion RFA for patients with low-to-intermediate risk localized prostate cancer has good clinical efficacy，little impact on urinary control and sexual function recovery，and few postoperative complications，which can be used as one of the treatment options for these patients.

KEY WORDS：focal radiofrequency ablation; prostate cancer; low-to-intermediate risk; localized; failure-free survival rate；urinary control；sexual function

摘要：目的 探讨局灶射频消融（RFA）治疗低危与中危局限性前列腺癌的疗效及其对患者术后尿控和性功能恢复的影响，以期探究微创方法治疗局限性前列腺癌的可行性。（剩余9403字）