哮喘与女性夜尿症的相关性：2005—2018年NHANES数据分析

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Correlation between asthma and nocturia in women：an analysis based on NHANES database from 2005 to 2018

YANG Chunxiao1，YANG Linbo1，LIU Ming2，WEN Yongan1，LI Xudong3

（1.School of Medicine，Xizang Minzu University，Xianyang 712082;2.Department of Urology，Beijing Hospital，Beijing 100730;3.Department of Urology，The First Affiliated Hospital of Xian Jiaotong University，Xian 710061，China）

ABSTRACT：Objective To analyze the relationship between asthma and nocturia in women based on the National Health and Nutrition Examination Survey （NHANES） database from 2005 to 2018，so as to provide reference for the prevention and treatment of female nocturia.Methods Female respondents aged ≥20 years with nocturia or asthma were selected from the 2005-2018 NHANES database.Those with both diabetes stroke and obstructive sleep apnea syndrome were excluded.A weighted analysis was conducted using a complex sampling design.The association between asthma and nocturia in women was evaluated with univariate analysis，propensity score matching （PSM），and multivariate logistic regression models.Results A total of 14 718 respondents were selected，of whom 1426 （9.7%） were diagnosed with asthma，and 4664 （31.7%） with nocturia.There is a significant correlation between asthma and nocturia （χ2=39.846，P<0.01）.Age，body mass index （BMI），smoking and race were also associated with nocturia （P<0.01）.Multivariate logistic regression analysis showed that，the age，BMI，smoking，race and asthma were correlated with the risk of nocturia，before PSM matching （P<0.05）.To eliminate confounding bias，PSM was applied，and generalized linear mixed model analysis after matching showed that the risk of nocturia remained high in asthma patients （OR=1.540，95%CI：1.320-1.800，P<0.01）.Conclusion Asthma is associated with nocturia in women，indicating that it may be an important risk factor for female nocturia.

KEY WORDS：asthma; women; nocturia; NHANES; logistic regression; complex sampling design

摘要：目的 基于2005—2018年美国国家健康与营养检查调查（NHANES）数据库分析哮喘与女性夜尿症的关系，为女性夜尿症的防治提供参考。（剩余6609字）