四维自动左房定量技术评价甲状腺功能亢进症患者左房结构及功能的临床价值

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ABSTRACTObjectiveToevaluate the leftatrial structureand function changes in patients withhyperthyroidism by four-dimensionalautomaticlefttrialquantificationtechnology（4DAutoLAQ），andtoexploreitsclinicalvalue.MethodsFifty ninepatients withhyperthyroidism（casegroup）and41 healthy individuals（control group）during thesame periodwere included inour hospital.Conventional echocardiographywas used to measure leftatrial anteroposteriordiameter in end-systole（LADs）， leftventricularend-diastolicdiameter（LVDd），leftventricularejectionfraction（LVEF），earlyandlatediastolicpeakbloodflow velocitiesacrossthemitral valve（E，A），earlyandlatediastolicmitralannularlateral wallmotionvelocities（e’，a’），and E/e'.4DAutoLAQwasusedtoobtainleftatrial maximumvolume（LAVmax），leftatrialminimumvolume（LAVmin），leftatrial pre-systolic volume（LAVpreA），leftatrialmaximumvolume index（LAVImax），leftatrial emptying volume（LAEV），leftatrial emptyingfractio（LAEF），leftatriallongiudinalandcicumferentialtraindurigthresevoirpase（LASrASrc）ral longitudinalandcicumferentialstraiduringtheonduitphase（LAScd，Acd-c），leftatriallongitudinalandciuertial strainduringthecontractionphase（LASct，LASct-c），andtheleftatrialstifessidex（LASI）wascalculated.Thediffrencesin above parameters between the two groupswere compared.The corelations between 4D Auto LAQ parametersand free triodothyronine（FT3），freethyroxine（FT4），andthyroid-stimulating hormone（TSH）inallstudysubjectswereanalyzed. ResultsConventional echocardiographyresultsshowedthatcomparedwiththecontrol group，thecase grouphad significantly increased LADs，LVDd，A，and a’（all P <0.05），while there were no significant diffrences in LVEF，E，e'，andE/e'.4D Auto LAQ results showedthatcomparedwiththecontrol group，thecasegrouphadsignificantlyincreasedLAVmin，LAVpreA，LAVImax， andLASI，and significantlydecreasedLAEF，LASr，LAScd，LASct，LASr- ∇⋅c ，and LASct-c（all P <0.05），while therewere no significantdrencsinLVax，AEVd-celaioalisoedatLVinAEF，ASdt， LASr-c，LASct-c，and LASI were allcorrelated with FT3，FT4，and TSH in all study subjects （all P <0.05）.Conclusion4D AutoLAQcanquantitativelyasssstheleftatrial structureand function changes inpatients withhyperthyroidism，offeringa reference for the precise clinical diagnosis of left atrial dysfunction and demonstrating certain value.

KEYWORDSFour-dimensionalautomaticleftatrialquantification technology;Echocardiography;Leftatrialstifness index;Hyperthyroidism;Atrialfunction，left

甲状腺功能亢进症（以下简称甲亢）是因甲状腺激素合成及分泌过量引发的内分泌疾病。（剩余9479字）