超声测量鼻烟窝桡动脉阻力指数联合炎症标志物预测脓毒血症的临床价值

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ABSTRACTObjectiveTo explore the clinical value of ultrasound-measured snuffox radial artery resistance index （SBRI）combined with inflammatory markers forpredicting sepsis.MethodsAtotalof113 patientswith suspected sepsis admitted to our hospital were enrolled and divided into a sepsis group（n=51） and a non-sepsis group（ n =62）according to the Sepsis-3.O diagnosticcriteria.SBRI was measured bybedsideultrasound.Procalcitonin（PCT），C-reactive protein（CRP）， interleukin-1（IL-1），interleukin-8（IL-8），interleukin-1β（IL-1β），tumor necrosis factor- α （TNF- α ），matrix metalloproteinase -2 （204 （MMP-2），matrixmetalloproteinase -9 （MMP-9），white blood cell count（WBC），and neutrophil count（NEU）were determined usingabiochemicalanalyzer.Thediferencesinaboveparametersbetweenthe twogroupswerecompared.Apredictive model based on SBRIcombined withinflammatory markers was established byLogistic regresion analysis.Receiveroperating characteristic（ROC）curve wasdrawn toanalyzeitsdiagnostic performance inpredicting sepsis.ResultsTheSBRI，PCT，IL-1， IL- 1β ，TNF- α ，MMP-2，MMP-9，WBC，and NEU were higher in the sepsis group than those in the non-sepsis group，with statistically significant differences（all P<0.05 ）.A predictive model based on SBRI combined with inflammatory markers was established by Logistic regression analysis：Logit （P） =-2.101+0.502 x SBRI+0.327×PCT+0.356×IL-1+0.031 × MMP-2.ROC curve analysis showedthattheareaunder thecurveforthecombinationof SBRIand inflammatorymarkers was0.773（95%CI：0.687-0.858），with a sensitivity of 82.0% and specificity of 91.0% .Conclusion The combination of SBRI and inflammatory markers can be used to predict sepsis，and demonstrates certain clinical value.

KEYWORDS Bedside ultrasound;Sepsis;Snuffbox radial artery resistance index;Inflammatory markers

脓毒症是一种危及生命的急危重症，通常由细菌或病毒感染引发免疫系统过度激活，进而导致全身炎症反应，可造成多器官功能障碍[1-2]。（剩余7381字）