经颅低强度脉冲超声在神经系统疾病中的应用进展

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ABSTRACTLow-intensity pulsed ultrasound（LIPUS），asan emerging non-invasive neuromodulation technology， demonstrates broad clinical potentialinthetreatmentofneurologicaldiseasesduetoitsuniqueadvantagessuchas highspatial resolutionandabsenceofionizing radiation damage.Byleveraging non-thermal biological mechanisms （such as mechanical stress andacousticstreaming efects），LIPUScanpreciselymodulate neuronal electricalactivityandneural networkfunction while maintainingcellarstructural integrity.Currentstudieshighlightitsremarkableneuroprotectivefectsandfunctional improvementsindiverseneurologicalconditions，includingcerebral infarction，Parkinson’sdisease，Alzheimer’sdisease， epilepsy，andmajordepresivedisoder.Tisarticlesystematicallyreviewtheulti-targetmechanismsof transcanialUSin neural function modulation，with emphasisonrecentadvancements inmotorrehabilitationand neurological symptomalleviation. Furthermore，it discusses current challenges and future directions for clinical translation.

KEYWORDS Ultrasonography，low-intensity pulsed;Ischemic stroke;Parkinson's disease;Alzheimer's disease

低强度脉冲超声（low-intensitypulsed ultrasound，LIPUS）是一种新型无创神经调控技术，其特点在于采用低强度（ <3W/cm2 0的脉冲式超声输出。（剩余13806字）