超声向量血流成像技术定量分析强直性脊柱炎患者颈动脉壁剪切应力分布特征

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ABSTRACTObjectiveTo quantitativelyanalyze thecarotid arterial wallshear stress（WSS）distributioncharacteristics inpatients withankylosing spondylitis（AS）byultrasoundvectorflowimaging（V-Flow）technology.MethodsAtotalof 39AS patientstreated inour hospitalwere selectedanddividedintoaninflammatory markerelevation group（17cases，GroupI：CRP> 10mg/L and/or ESR ⩾ 15 mm/h） and a normal inflammatory marker group（22 cases，Group II ：CRP<10 mg/L and ESR<15 mm/h） basedontheresultsof inflammatory markertest.Aditionally，21age-andsex-matchedhealthyvolunteers wereselecteds the control groupduring thesame period.Carotid intima-media thickness（IMT）was measuredbyconventionalultrasound，andVFlowtechnologywas employed toobtainthe maximum and average valuesof WSSatthecommoncarotidarterybifurcationand mid-segment （ WSSmax ， wssmean ）.The differences in above parameters among the groupswere compared.The correlations between V-Flow parameters and inflammatory markers were analyzed.ResultsThe WSSmax and WSSmean at the common carotid arterybifurcationweresignicantlylowerthantoseatthecarotidarterymid-segmentrespectively，withstatisticalysignificant differences（all P<0.05 ）.The ψssmax and WSSmean at the common carotid artery bifurcation and mid-segment in Group I were lower than those in Group II and the control group，and the WSS max at the common carotid artery bifurcation in Group II was lower than that in the control group，with statistically significant differences（all P<0.05 ）.There was no statistically significant diference in IMT among the groups.Correlation analysis showed that both ψSSmax and WSSmean at the common carotid artery bifurcation in AS patients were negatively correlated with CRP and ESR levels ，respectively（all P <0.05）.ConclusionV-Flow technologycanquantitativelyanalyzetheWSSdistributioncharacteristics inthecarotidarterywallofASpatients，providing valuable imaging evidence for clinical early intervention.

KEYWORDS Ultrasound vector flow imaging;Ankylosing spondylitis;Carotid artery;Wall shear stress

强直性脊柱炎（ankylosing spondylitis，AS）是一种以脊柱、骶髂关节和脊柱附着点等中轴骨骼的炎性损伤为特征的慢性炎症性疾病。（剩余7621字）