激光共聚焦显微内镜在溃疡性结肠炎诊断和预后评估中的应用进展

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Abstract Ulcerative colitis （UC） is a chronic non ‐ specific intestinal inflammatory disease with unclear etiology. Genetic factors， environmental factors， immune induction， gut microbiota， and infections might be involved in the development of UC. Its clinical manifestations include recurrent mucopurulent bloody stools， increased defecation frequency， abdominal pain， etc. It often shows an alternating pattern of inflammatory remission and recurrence. Endoscopic examination plays a crucial role in the diagnosis and prognosis assessment of UC. Confocal laser endomicroscopy （CLE） can accurately assess the disease activity， predict the disease relapse， and detect the neoplastic lesions. It is conducive to the etiological and mechanism studies as well as the selection of biologicals. The emergence of CLE‐based molecular endoscopy holds promise for application in the disease severity prediction， biologicals selection， and prognosis assessment of UC. This article systematically reviewed and evaluated the application of CLE in the diagnosis and prognosis assessment of UC.

Key words Colitis， Ulcerative; Confocal Laser Endomicroscopy; Diagnosis; Prognosis

溃疡性结肠炎（ulcerative colitis， UC）是一种肠道慢性非特异性炎性疾病，在欧美国家较为多见。（剩余18552字）