温敏微胶囊的制备及其控释性能

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中图分类号：TQ323.8 文献标志码：A

Abstract： To improve the utilization eficiencyof pyraclostrobin （Pyr），atemperature-sensitive pyraclostrobin microcapsule was successfully prepared using an interfacial polymerizationmethod basedonanoil-in-water（O/W）emulsion template.The microcapsule consisted ofa mixed core of Pyrand eicosane，with a polyurethane shell formed by the polymerizationof isophorone disocyanate （IPDI）andpolyethylene glycol（PEG-400）.The morphology，structure，andthermal stabilityof the microcapsuleswerecharacterizedbysaningelectronmcroscopy （SEM），transmissionelectronmicroscopy（TE），Fourier transform infrared spectroscopy （FT-R），X-rayphotoelectronspectroscopy （XPS），thermogravimetricanalysis （TGA），and diferential scanningcalorimetry （DSC）.Theefects of different Pyr dosages onthe encapsulation efficiencyand drugloading capacity of the synthesized microcapsules were evaluated using ultraviolet-visible spectrophotometry （UV-Vis），and in vitro temperature-responsivereleasecapabilityof themicrocapsuleswas tested.Resultsshowed thatthe microcapsules exhibiteda smooth and uniform surface，with an average size of 7.0μm .The optimal encapsulation efficiency reached 76.42% ，witha drug loading capacity of 22.72% .Invitro release tests demonstrated that the microcapsules exhibited thermally responsive controlled-release properties.Specifically， Pyr was released slowly at low temperatures （<34.5∘C） ，while thereleaserate increased significantly at high temperatures （>34.5∘C） .The release kinetics followed a first-order kinetic model. The study confirmedthatthe incorporationofphase-change materials efectivelyenabledthetemperature-responsivereleaseofPyr.This intelligent controlled-release pesticide formulation provides a promising solution for sustainable agriculture.

Keywords： pyraclostrobin；interfacial polymerization；thermosensitive microcapsule；phase transition；controled release property

农药的使用是控制农作物真菌类病害、保障农业生产安全不可或缺的手段⑴。（剩余11925字）