pH/ROS双重刺激响应性微凝胶多药共载体系的构建
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中图分类号：0648 文献标志码：A
Construction of pH/ROS Dual-Responsive Microgel Multidrug Co-delivery System
LIU Xiaopei， LIU Fangyi， XIE Mengyang， XU Shouhong （Key Laboratory for Advanced Materials，School of Chemistry and Molecular Engineering，East China University of Science and Technology， Shanghai 200237， China）
Abstract：Smartresponsivenanocarriers have emergedas apromising strategy for tumor therapy，demonstratingsignificant clinicalpotentialdue totheirhigh targeting capabilityandexcellntbiocompatibility.Anamphiphiliccopolymer， poly（propylene sulfide）-poly（3-acrylamidophenylboronic acid-co-poly（ethylene glycol） methyl ether methacrylate） （PPSk. 1 P（APBAm..co.OEGMAn） ），was designed and synthesized. Through self-assembly，reactive oxygen species （ROS）-responsive polymeric micelles were obtained. The hydrophilic I Λo（APBAm..co.OEGMAn） ）shell was further crosslinked using the polyphenolicdrug proanthocyanidin （PC），forming a boronate estercovalent network that enhanced the stabilityof the nanocarier while introducing pHresponsivenessand yielding dual pH/ROS-responsive microgel carriers.The particle size， surface morphology，and crossinking behavior of the microgels were characterized using dynamic light scattring （DLS）， scaning electron microscopy （SEM），andultraviolet-visible（UV-Vis）spectroscopy.Thedrug-loadingandreleasebehavior of smal-molecule doxorubicin （DOX）and macromolecular bovine serum albumin （BSA） were investigated，demonstrating eficientdrug encapsulationand stimuli-responsiverelease.Theresultsconfirmedthatthe microgelcarrier exhibited pH/ROS dualresponsiveness，a stable independent loading of multiple drugs，and controled drug release.This study providesa scientific foundation for precision drugdelivery，intellgent release systems，andovercoming multidrug resistance incacer therapy.
Key words：smart responsive；nanocarier；polymer micelle；core-shellstructure；microgel;drugcontrolledrelease
癌症是21世纪的重大社会、公共卫生和经济问题⑴，其治疗障碍不仅源于癌症本身，还涉及个体差异、免疫反应、心理及社会环境等多方面因素[2.3]。（剩余19137字）
