贵州穿青人微单倍型遗传背景分析与法医学效能评估

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performance and genetic background alyses Chuanqing population using a self-constructed microhaplotype panel

ZHANG Hongling GU Changyun WANG Qiyan HuANG Xiaolan RAN Qianchong REN Zheng LIu Yubo LuOYansha PAN Shuaiji YANG Meiqing JI Jingyan JINXiaoye

Abstract：ObjectiveToinvestigatetheethnicorigin Chuanqing people，onethe largest unidentifiedethnic groups in ， Chi，andalyze its geneticrelationships with surounding populations.Methods Based o self-developed microhaplotype system，weconducted genotyping andalyzed the genetic distribution microhaplotype loci and their forensicapplicabilityin Chuanqing populationin Province.Usingthemicrohaplotypedatafrom different intercontinentalpopulationsand previouslyreporteddatafrom Han populationlivingin Province，wesystematically investigatedthegeneticbackgroundChuanqingpeoplethroughpopulation geneticapproaches，includinggeneticdistance estimation，prncipalcomponentalysis，and phylogenetic treeconstruction.ResultsAmongthe studied populationthe numberhaplotypepermicrohaplotyperanged from6to25.Theaverageexpected heterozygosity （He），observed heterozygosityH）iai）dpbbilituio（E）e37 respectively.Thecumulativepower discrimition （CPD）andcumulativeprobability exclusion （CPE）forthese33loci were 1-2.62×10-41 and 1-7.64×10-17 respectively. Population genetic alyses revealed that the Chuanqing population had close genetic relationships withtheEastAsianpopulations，especiallthelocal Hanpopulation，BejingHanpopulation andtheHanpopulationsliving insouthernChi.ConclusionThe33microhaplotypes exhibithighlevels geneticdiversity in the Chuanqing population，highlighting their potentials forboth forensic identification and parentage testing.The Han populations might have contributed a significant amount genetic materialto the Chuanqing population during the formation and development the latter.

Keywords： Chuanqing population; microhaplotype; genetic structure; forensic performance

祖先成分推断是法医学研究的核心方向之一，它通过科学可靠的方法显著提升刑事侦查的效率和精准性。（剩余14864字）