Klotho蛋白抑制慢性肾脏病血管钙化的作用及其机制研究进展

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[中图分类号]R692.16［文献标志码]A[文章编号] 2097-5716（2025）04-0594-09

DOI： 10.13308/j.issn.2097-5716.2025.04.022

Research progress on role and mechanisms of Klotho protein in inhibiting vascular calcification of chronic kidney diseaseQIAN Jingrong'， ZHANG Qi1 ，YANG Xuli’，LIU Qifeng1，²（1. Department of Nephrology， Afiliated Kunshan Hospital of Jiangsu University，Suzhou Jiangsu 2153O0；2.Gusu Schol，Nanjing Medical University，Suzhou Jiangsu 215006，China）

[Abstract]Vascular calcification is a common complication in patients with chronic kidney disease （CKD）. With the progression of CKD，both the incidence and severityof vascular calcification graduall increase，which seriously affects the prognosis of patients.However，there are currently no clinically proven therapies specifically targeting vascular calcification for improvement. Klotho is aprotein possesing functions suchasantioxidant，antiinflammatory，and regulation of calcium-phosphate metabolism.It modulates multiple calcification-related pathways，including fibroblast growth factor-23，Runt-related transcription factor 2，Wnt/ β -catenin，phosphate transporters，and the receptor activator of nuclear factor KB，thereby inhibiting the formation of vascular calcification. Consequently，Klotho may bea promising novel therapeutic target for vascular calcification.This article reviews therole of Klotho in inhibiting vascularcalcification and its underlying mechanisms in CKD patients.

[Key words] Klotho protein; chronic kidney disease;vascular calcification;mechanism

血管钙化是指钙、磷在血管壁的病理性沉积，是慢性肾脏病（chronickidneydisease，CKD）等多种慢性疾病以及衰老的一种常见病理改变[1]。（剩余22423字）