心电图P波参数与脑白质病变的相关性

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[关键词]P波参数；脑白质病变；独立危险因素； ΔV1 导联 P 波终末电势；Fazekas量表 [中图分类号]R743;R540.4［文献标志码]A[文章编号]2097-5716（2025）04-0523-04 DOI： 10.13308/j.issn.2097-5716.2025.04.009

[引用格式]，.心电图P波参数与脑白质病变的相关性［J].实用心电与临床诊疗，2025，34（4）：523-526.

Asociation between electrocardiogram P-wave parameters and white mater lesionsGUAN Jingjing ， LIU Ying（Cardiac Function Testing Section，Department of Ultrasound Medicine，Nanjing Drum Tower Hospital， the Affiliated Hospital of Nanjing University Medical School，Nanjing Jiangsu 21Oo08， China） [Abstract]ObjectiveTo investigate the association between electrocardiogram （ECG）P-wave parameters and the severity of white matter lesions （WMLs），providing a scientific basis for the prevention and treatment of WMLs. MethodsA total of 289 hospitalized patients with WMLs meeting the inclusion criteria were selected as study objects，and allparticipants underwent routine 12-lead ECG and cranial magnetic resonance imaging examination. These patients were divided into no-mild group（158 cases）and moderate-severe group （131 cases）according to the Fazekas scale scores.We colected clinical data，medical history，ECG P-wave parameters including P-wave duration，P-wave axis and terminal force of P-wave in lead V1（PTFV1） ，lipid profile，and other data of both groups for comparative analysis.Logistic regresion model was used to analyze independent risk factors for WMLs. ResultsIn the moderate-severe group，their age，and the proportions of cases with history of hypertension or diabetes and PTFV1>4000μV ·ms were all significantly higher than those in the no-mild group，all with statistically significant differences （all P<0.01 ）. Multivariate Logistic regression analysis indicated that increased age，hypertension，diabetes，and PTFV1>4000μV⋅ms were all independent risk factors for WMLs. Conclusion The non-invasive ECG index PTFV1 is cost-effective， convenient and easily accessible. It can be used to assess atrial abnormalitie. It contributes to the prevention and treatment of WMLs.

[Key words]P-wave parameter；white matter lesion；independent risk factor;terminal force of P-wave in lead ΔV1 Fazekas scale

脑白质病变（whitematterlesions，WMLs）是脑小血管疾病的主要类型之一，而脑小血管疾病与缺血性脑卒中、痴呆等疾病关系密切[1-2]。（剩余6520字）