阿尔茨海默病患者血清叶酸、维生素 B12 和 25羟维生素D水平变化及其诊断效能
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[中图分类号] R446.1 [文献标志码]A ［文章编号]2097-5716（2025）04-0543-05
DOI： 10.13308/j.issn.2097-5716.2025.04.013
Changes serum folate，vitamin B12 and 25-hydroxyvitamin D levels in patients with Alzheimer's disease and their diagnostic efficiencyHE Yuqi'，PAN Mingzhi’，ZHANG Xiaobin²， ZHANG Lu’（1. Laboratory，2. Geriatric Psychiatry，Suzhou Guangji Hospital， Suzhou Jiangsu 215137， China）
[Abstract] ObjectiveTo analyze serum folate，vitamin B12（VB12 ）and 25-hydroxyvitamin D [25（OH）D] levels in patients with Alzheimer's disease（AD），and to evaluate the corelation these three indicators with patients’cognitive function and activities daily living，aswellastheir diagnostic eficiency for AD. MethodsSixty AD patients（AD group）and 48 elderly healthy individuals undergoing physical examination （control group） were selected. Serum levels folate， VB12 ，and 25（OH） D were measured in both groups. Cognitive function was asessed using the mini-mental state examination （MMSE），while activities daily living were evaluated using the activity daily living scale（ADL）.ROC curves were ploted to analyze the diagnostic efficiency. ResultsSerum folate， VB12 ，and 25（OH） D levels，as well as MMSE and ADL scores，were all significantly lower in the AD group compared to the control group （all P<0.05 ）. The three serum indicators were positively correlated with both MMSE and ADL scores （all P<0.05 ）. ROC curve analysis revealed that the combined detection folate， VB12 ，and 25（OH） D achieved an AUC value O.798 for AD diagnosis，with a sensitivity 78.3% and a specificity 72.9% . These values were all significantly higher than those any single indicator used alone. ConclusionSerum folate， VB12 ，and 25（OH） D levels are significantly decreased in AD patients，which are positively corelated with the degree decline in patients’cognitive function and activities daily living. The combined detection these three markers could improve the diagnostic effciency for AD.
[Key words]Alzheimer's disease; folate; vitamin B12 ; 25-hydroxyvitamin D； diagnostic efficiency
阿尔茨海默病（Alzheimer'sdisease，AD）作为一种与老年增龄紧密相关的慢性进行性综合征，具有复杂多样的临床症状，主要包括记忆力、认知功能的全面衰退以及人格和行为的明显改变。（剩余7805字）