NT-proBNP、微循环阻力指数与急性前壁心肌梗死PCI术后左心室不良重构的关系

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[中图分类号] R540.41［文献标志码]A [文章编号] 2097-5716（2025）04-0553-04

DOI： 10.13308/j.issn.2097-5716.2025.04.015

Relationship between NT-proBNP，index of microcirculation resistance and adverse left ventricular remodeling after PCI in acute anterior wall myocardial infarctionLI Xin， HUANG Haiyan，YE Juan [Department of Cardiovascular Medicine，Chongqing Red Cross Hospital （the People's Hospital of Jiangbei District），Chongqing 400015，China]

[Abstract] ObjectiveTo explore the relationship between N-terminal pro-brain natriuretic peptide （NT-proBNP），index of microcirculation resistance（IMR），andadverse leftventricular remodeling after percutaneous coronary intervention （PCI） in acute anterior wall myocardial infarction.MethodsWe selected 105 patients with acute anterior wall myocardial infarction who hadundergone PCI surgery，and they all underwent echocardiography and other examinations.Based on the diffrence in the increment rate of left ventricular volume， these patients were divided into an adverse remodeling group（39 cases）and a non-remodeling group（66 cases）. The general information，biochemical indicators，and other examination results were compared between the two groups.Statistically significantdata from univariateanalysis were included in multivariate Logistic regresion analysis，in order to explore the relationship between NT-proBNP，IMR，and adverse left ventricular remodeling. ResultsThe LVEF，early diastolic maximum velocity/end diastolic maximum velocity（E/A）of the mitral valve in the adverse remodeling group were significantly lower than those in the non-remodeling group，while NT-proBNP and IMR were significantly higher than those in the non-remodeling group （all P<0.01 ）. Logistic regression analysis showed that LVEF，E/A，NT-proBNP，and IMR were independent risk factors foradverse left ventricular remodeling after PCI in acute anterior wall myocardial infarction （all P<0.01 ）. ConclusionClinically，prevention and treatment measures for adverse left ventricular remodeling after PCI in acute anterior wall myocardial infarction can be developed based on NT-proBNP and IMR to reduce the occurrence of adverse left ventricular remodeling. [Key words]N-terminal pro-brain natriuretic peptide；index of microcirculatory resistance；acute anterior wall myocardial infarction； percutaneous coronary intervention； adverse left ventricular remodeling

急性前壁心肌梗死在心电图上主要表现为ΔV1-V5 导联的缺血性变化，主要由冠状动脉急性阻塞导致相应心肌区域供血不足、心肌坏死而引起。（剩余4318字）