基于网络药理学及分子对接技术分析蛇床子治疗早泄作用机制

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[中图分类号］R285 [文献标志码］A [文章编号]0256-7415（2025）09-0212-08

DOI：10.13457/j.cnki.jncm.2025.09.038

Analysis of Therapeutic Mechanism of Cnidium Monnieri in Treating Premature Ejaculation Based on Network Pharmacology and Molecular Docking Technology

ZHANG Hong1，LIU Yezi，GAO Yating1，HUANG Shuxian²，OU Yangfan1，XIE Zuogang1 1.WenzhouHospitalofIntegratedTraditoalChineseandWesteMedicine，WenzhouZhejang325oo，China；.TheSecondPeople's Hospital of Longwan District of Wenzhou，Wenzhou Zhejiang 325ooO，China

Abstract：Objective：To analyze the main targets and therapeutic mechanisms of Cnidium Monnieri in treating premature ejaculation using network pharmacology and molecular docking technology.Methods：The main active components and their targets of Cnidium Monnieri were obtained from the TCMSP database.Disease-related targets were retrieved from the DrugBank and GeneCardsdatabases.A Cnidium Monnieri-active components-intersecting gene network was constructed.The protein-protein interaction （PPI） network was obtained using the String database.Gene Ontology（GO）analysisand Kyoto Encyclopedia of Genes and Genomes（KEGG）pathway analysis were performed using the DAVID database，folowed by molecular docking.Results：A total of 2O activecomponents and 10 key targets of Cnidium Monnieri were identified.GO functional enrichment analysis showed that Cnidium Monnieri mainly regulates functions in the membrane，nucleus，cytoplasm，plasma membrane，transferase，receptor，and kinase. KEGG pathway enrichment analysis indicated that Cnidium Monnieri is involved in the PI3K-Akt signaling pathway， thyroid hormone signaling pathway，cancer pathway，and prostate cancer pathway.Molecular docking results showed stable binding of Cnidium Monnieri'sactive component（Osthole）to targets such as AKT1，ESR1，EGFR，and JUN.

Conclusion：Cnidium Monnieri may exert its therapeutic effects by Osthole on premature ejaculation by acting on targets such as AKT1，ESR1，EGFR，and JUN through the regulation of the PI3K-Akt signaling pathway，thyroid hormone signaling pathway， cancer pathway，and prostate cancer pathway.

Keywords：Premature ejaculation；Cnidium Monnieri；Network pharmacology；Osthole； Signaling pathways

早泄是常见的男性性功能障碍疾病，表现为较短的阴道内射精潜伏时间，缺乏射精控制能力，对患者和（或）性伴侣造成困扰和人际交往障碍。（剩余8374字）